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Clinical Trials/NCT05587400
NCT05587400
Recruiting
Not Applicable

The Consistency of Cardiac Output Measured by Electrical Cardiometry and Pulmonary Artery Catheter in Cardiac Surgery Patients With Pulmonary Arterial Hypertension or Right Heart Dysfunction

Shanghai Zhongshan Hospital1 site in 1 country199 target enrollmentJuly 27, 2022

Overview

Phase
Not Applicable
Intervention
passive leg raising
Conditions
Pulmonary Arterial Hypertension
Sponsor
Shanghai Zhongshan Hospital
Enrollment
199
Locations
1
Primary Endpoint
cardiac output by pulmonary artery catheter
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

Currently, the gold standard method to estimate CO in patients with PAH or RV dysfunction is pulmonary artery catheter (PAC), however, the invasiveness and complexity of PAC has limited its usefulness in many clinical scenarios. By measuring the thoracic electrical bioimpedance, electrical cardiometry (EC) technique has been reported to noninvasively estimate cardiac output (CO) and other parameters related to cardiac contractility and fluid status in various cardiovascular disorders. However, in patients with pulmonary arterial hypertension (PAH) and/or right ventricular (RV) dysfunction, few study has been reported. The aim of this study is to evaluate the agreement between CO measured by PAC as the referenced method and CO measured by EC technique in patients with PAH and/or RV dysfunction.

Registry
clinicaltrials.gov
Start Date
July 27, 2022
End Date
December 31, 2024
Last Updated
3 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Sponsor
Shanghai Zhongshan Hospital
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • adult cardiac surgery patients
  • pulmonary artery hypertension and/or right heart dysfunction
  • mechanical ventilation

Exclusion Criteria

  • life threatening arrhythmia
  • severe valve regurgitation
  • left ventricular ejection fraction less than 30%
  • patients with mechanical circulatory support

Arms & Interventions

patients with pulmonary artery hypertension and/or right ventricular dysfunction

Intervention: passive leg raising

patients with pulmonary artery hypertension and/or right ventricular dysfunction

Intervention: dobutamine test

patients with pulmonary artery hypertension and/or right ventricular dysfunction

Intervention: inhaled nitric oxide

Outcomes

Primary Outcomes

cardiac output by pulmonary artery catheter

Time Frame: 30 minutes after nitric oxide inhalation

measuring cardiac output using pulmonary artery catheter

cardiac output by electrical cardiometry

Time Frame: 30 minutes after nitric oxide inhalation

measuring cardiac output using electrical cardiometry

Study Sites (1)

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