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Clinical Trials/NCT04604886
NCT04604886
Unknown
Not Applicable

The Consistency of Cardiac Output Measured by Pulmonary Artery Catheter and LiDCO in Cardiac Surgical Patients

Shanghai Zhongshan Hospital1 site in 1 country40 target enrollmentSeptember 30, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cardiac Surgery
Sponsor
Shanghai Zhongshan Hospital
Enrollment
40
Locations
1
Primary Endpoint
Cardiac Output measurement after PLR
Last Updated
5 years ago

Overview

Brief Summary

  1. To evaluate the consistency of cardiac output measured by pulmonary artery catheter and LiDCO in cardiac surgical patients
  2. To evaluate whether different hemodynamic monitoring methods can accurately detect the trend of cardiac output changes

Detailed Description

Close monitoring of cardiac output (CO), especially in patients before and after intervention(such as volume expansion, diuresis, vasoconstriction, vasodilation therapy), could help to adjust the treatment strategy in cardiac surgical patients. Pulmonary artery catherization (PAC) has been used for hemodynamic monitoring for more than four decades. In spite of its invasiveness, it remains the clinical reference method for the assessment of CO at the bedside. Nowadays, many less invasive alternatives, such as LiDCO Rapid Pulse Contour Analysis System (LiDCO Ltd., Cambridge, United Kingdom), are already available on market. However, consistency between different hemodynamic monitoring results still raise concern. And whether hemodynamic monitoring could accurately detect the changes of these parameters before and after intervention is an important issue in clinical practice. In this study, the investigators are going to collect CO and changes of CO from PAC and LiDCO before and after intervention (passive leg raising and dobutamine stress test) in cardiac surgical patients. Our resulst could provide important reference for cardiac surgical patients how to choose appropriate hemodynamic monitoring tools and how to interpret the results of hemodynamic monitoring.

Registry
clinicaltrials.gov
Start Date
September 30, 2020
End Date
June 30, 2024
Last Updated
5 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Sponsor
Shanghai Zhongshan Hospital
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • cardiac surgery
  • hemodynamic monitoring (PAC, LiDCO)
  • mechanical ventilation

Exclusion Criteria

  • cardiac arrhythmia
  • moderate to severe aortic, mitral and tricuspid regurgitation

Outcomes

Primary Outcomes

Cardiac Output measurement after PLR

Time Frame: 1 minute after PLR

Cardiac Output measured after PLR

Baseline Cardiac Output measurement

Time Frame: within1 minute at baseline position

Cardiac Output measured at baseline position (horizontal position)

Cardiac Output measurement after Dobutamine stress test

Time Frame: 5 minutes after dobutamine stress test

Cardiac Output measured after dobutamine stress test

Study Sites (1)

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