Carbidopa
- Generic Name
- Carbidopa
- Brand Names
- Dhivy, Duodopa, Duopa, Lodosyn, Parcopa, Rytary, Sinemet, Stalevo
- Drug Type
- Small Molecule
- Chemical Formula
- C10H14N2O4
- CAS Number
- 28860-95-9
- Unique Ingredient Identifier
- KR87B45RGH
- Background
Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with levodopa. An individual formulation containing...
- Indication
Carbidopa is indicated with levodopa for the treatment of symptoms of idiopathic Parkinson disease, postencephalitic parkinsonism and symptomatic parkinsonism followed by carbon monoxide or manganese intoxication.
The combination therapy is administered for the reduction of levodopa-driven nausea and vomiting.
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- Associated Conditions
- Parkinson's Disease (PD), Parkinsonism post encephalitic, Symptomatic Parkinson Disease, Levodopa-driven nausea and vomiting
- Associated Therapies
- -
Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients.
- Conditions
- Interventions
- First Posted Date
- 2010-10-25
- Last Posted Date
- 2015-10-19
- Lead Sponsor
- Bial - Portela C S.A.
- Target Recruit Count
- 427
- Registration Number
- NCT01227655
- Locations
- 🇵🇹
Bial - Portela & Cª, S.A., S. Mamede do Coronado, Portugal
Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia
- First Posted Date
- 2010-09-30
- Last Posted Date
- 2016-03-28
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 12
- Registration Number
- NCT01212484
Acute Effects of Preladenant (SCH 420814) on Dyskinesia and Parkinsonism in Levodopa Treated Participants (P05550)
- Conditions
- Interventions
- First Posted Date
- 2009-02-16
- Last Posted Date
- 2018-11-07
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 12
- Registration Number
- NCT00845000
Peripheral Dopamine in Postural Tachycardia Syndrome
- Conditions
- Interventions
- First Posted Date
- 2008-05-29
- Last Posted Date
- 2022-01-24
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 32
- Registration Number
- NCT00685919
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Parcopa Versus Carbidopa-levodopa in a Single Dose Cross-over Comparison Study
- Conditions
- Interventions
- First Posted Date
- 2008-01-10
- Last Posted Date
- 2023-03-14
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 20
- Registration Number
- NCT00590122
- Locations
- 🇺🇸
PDCMDC 6550 Fannin, Suite 1801, Houston, Texas, United States
Augmenting Effects of L-DOPS With Carbidopa and Entacapone
- Conditions
- Interventions
- First Posted Date
- 2007-10-23
- Last Posted Date
- 2014-07-17
- Target Recruit Count
- 14
- Registration Number
- NCT00547911
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2016-01-05
- Target Recruit Count
- 200
- Registration Number
- NCT00218075
- Locations
- 🇺🇸
University of Texas Health Science Center, Houston, Texas, United States
Treatment of Supine Hypertension in Autonomic Failure
- Conditions
- Interventions
- Drug: PlaceboDrug: ClonidineDrug: Nitroglycerin transdermalDrug: Dipyridamole/ Aspirin (Aggrenox)Drug: Desmopressin (DDAVP)Drug: SildenafilDrug: NifedipineDrug: HydralazineDrug: HydrochlorothiazideDrug: BosentanDrug: DiltiazemDrug: EplerenoneDrug: guanfacineDietary Supplement: L-arginineDrug: captoprilDrug: carbidopaDrug: losartanDrug: metoprolol tartrateDrug: nebivolol hydrochlorideDrug: prazosin hydrochlorideDrug: tamsulosin hydrochlorideOther: Head-up tilt.Drug: aliskirenOther: Local heat stress
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-10-13
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 152
- Registration Number
- NCT00223717
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
A Single Center, Randomized, Double-blind, Crossover Pilot Trial Comparing the Onset of Action of Parcopa™ With Sinemet® in Subjects With Stable Parkinson's Disease
- Conditions
- First Posted Date
- 2005-08-31
- Last Posted Date
- 2013-09-04
- Lead Sponsor
- UCB Pharma
- Registration Number
- NCT00139880
- Locations
- 🇺🇸
Schwarz, Milwaukee, Wisconsin, United States
A Multicenter, Open-label Trial to Assess Subject Preference of PARCOPA, Carbidopa/Levodopa Orally Disintegrating Tablets, Compared to Conventional Carbidopa/Levodopa Tablets in Subjects With Stable Parkinson's Disease
- Conditions
- First Posted Date
- 2005-08-31
- Last Posted Date
- 2014-10-20
- Lead Sponsor
- UCB Pharma
- Registration Number
- NCT00139867
- Locations
- 🇺🇸
Schwarz, Milwaukee, Wisconsin, United States
Drug Development Updates
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