Baclofen
- Generic Name
- Baclofen
- Brand Names
- Fleqsuvy, Gablofen, Kemstro, Lioresal, Lyvispah, Ozobax
- Drug Type
- Small Molecule
- Chemical Formula
- C10H12ClNO2
- CAS Number
- 1134-47-0
- Unique Ingredient Identifier
- H789N3FKE8
- Background
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FD...
- Indication
Oral baclofen is indicated for the treatment of spasticity resulting from multiple sclerosis and is particularly useful for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. It may also be used to treat patients with spinal cord injuries and other spinal cord diseases. Baclofen should not be used to treat skeletal muscle spasms...
- Associated Conditions
- Alcohol Dependency, Severe Spasticity, Spasticity, Flexor spasm, Severe cerebral origin Spasticity, Severe spinal cord origin Spasticity
- Associated Therapies
- -
Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis
- Conditions
- Interventions
- First Posted Date
- 2012-12-06
- Last Posted Date
- 2022-04-25
- Lead Sponsor
- RVL Pharmaceuticals, Inc.
- Target Recruit Count
- 353
- Registration Number
- NCT01743651
- Locations
- 🇺🇸
Osmotica Study Site-127, Pittsburgh, Pennsylvania, United States
🇺🇸Osmotica Study Site-129, Seattle, Washington, United States
🇺🇸Osmotica Study Site-131, Cincinnati, Ohio, United States
Efficacy and Safety of Baclofen for Maintenance of Abstinence in Alcohol Dependent Patients
- First Posted Date
- 2012-11-30
- Last Posted Date
- 2014-07-30
- Lead Sponsor
- Ethypharm
- Target Recruit Count
- 316
- Registration Number
- NCT01738282
- Locations
- 🇫🇷
Hopital Beaujon, Clichy, France
🇫🇷CHU, Nantes, France
🇫🇷Centre hospitalier, Pont du Casse, France
Baclofen for the Treatment of Alcohol Drinkers
- First Posted Date
- 2012-05-23
- Last Posted Date
- 2017-10-03
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 323
- Registration Number
- NCT01604330
- Locations
- 🇫🇷
Paris Descartes University, Paris, France
Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy
- First Posted Date
- 2011-07-01
- Last Posted Date
- 2017-08-29
- Lead Sponsor
- Boston Children's Hospital
- Registration Number
- NCT01386255
- Locations
- 🇺🇸
Children's Hospital Boston, Boston, Massachusetts, United States
Baclofen for the Treatment of Alcohol Dependence
- First Posted Date
- 2010-12-24
- Last Posted Date
- 2014-09-05
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 56
- Registration Number
- NCT01266655
- Locations
- 🇩🇪
Department of Psychiatry, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
- Conditions
- Interventions
- First Posted Date
- 2010-12-23
- Last Posted Date
- 2020-01-22
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 366
- Registration Number
- NCT01265550
- Locations
- 🇺🇸
Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama, United States
🇺🇸VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda, California, United States
🇺🇸VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts, United States
Baclofen and Hypoxia-induced Periodic Ventilation
- First Posted Date
- 2010-03-30
- Last Posted Date
- 2012-10-31
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 53
- Registration Number
- NCT01095679
- Locations
- 🇫🇷
Pitié-Salpêtrière Hospital, Paris, France
A Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking
- First Posted Date
- 2010-02-26
- Last Posted Date
- 2013-10-17
- Lead Sponsor
- Brown University
- Target Recruit Count
- 14
- Registration Number
- NCT01076283
- Locations
- 🇺🇸
Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island, United States
Structure and Function of the Gastro-esophageal Junction
- Conditions
- Interventions
- First Posted Date
- 2010-01-21
- Last Posted Date
- 2011-06-02
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 24
- Registration Number
- NCT01053585
- Locations
- 🇨🇭
Division of Gastroenterology, Zurich, Switzerland
Baclofen to Reduce Alcohol Use in Veterans With HCV
- First Posted Date
- 2009-11-05
- Last Posted Date
- 2016-02-08
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 180
- Registration Number
- NCT01008280
- Locations
- 🇺🇸
VA San Diego Healthcare System, San Diego, CA, San Diego, California, United States
🇺🇸VA Medical Center, Minneapolis, Minneapolis, Minnesota, United States
🇺🇸VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California, United States
Drug Development Updates
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