Baclofen

Generic Name
Baclofen
Brand Names
Fleqsuvy, Gablofen, Kemstro, Lioresal, Lyvispah, Ozobax
Drug Type
Small Molecule
Chemical Formula
C10H12ClNO2
CAS Number
1134-47-0
Unique Ingredient Identifier
H789N3FKE8
Background

Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FD...

Indication

Oral baclofen is indicated for the treatment of spasticity resulting from multiple sclerosis and is particularly useful for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. It may also be used to treat patients with spinal cord injuries and other spinal cord diseases. Baclofen should not be used to treat skeletal muscle spasms...

Associated Conditions
Alcohol Dependency, Severe Spasticity, Spasticity, Flexor spasm, Severe cerebral origin Spasticity, Severe spinal cord origin Spasticity
Associated Therapies
-
Clinical Trials
Related News

Efficacy of Baclofen Vs Naltrexon in Achieving & Maintaining Abstinence in Alcohol Dependence.

Not Applicable
Not yet recruiting
Conditions
Alcohol Liver Disease
Interventions
Drug: Naltrexon
Drug: Baclofen
First Posted Date
2023-12-19
Last Posted Date
2023-12-19
Lead Sponsor
Institute of Liver and Biliary Sciences, India
Target Recruit Count
110
Registration Number
NCT06175507
Locations
🇮🇳

Institute of Liver & Biliary Sciences (ILBS), New Delhi, Delhi, India

Baclofen for Children With Rumination Syndrome

Phase 3
Recruiting
Conditions
Rumination Syndrome
Interventions
Drug: Placebo
Drug: Baclofen
First Posted Date
2023-08-04
Last Posted Date
2024-07-26
Lead Sponsor
Nationwide Children's Hospital
Target Recruit Count
50
Registration Number
NCT05975684
Locations
🇺🇸

Nationwide Children's Hospital, Columbus, Ohio, United States

Effect of Baclofen to Prevent Post-Traumatic Stress Disorder

First Posted Date
2023-05-26
Last Posted Date
2024-06-17
Lead Sponsor
Nantes University Hospital
Target Recruit Count
94
Registration Number
NCT05877807
Locations
🇫🇷

Montpellier University Hospital, Montpellier, Hérault, France

🇫🇷

Nantes University Hospital, Nantes, Loire-Atlantique, France

🇫🇷

Angers University Hospital, Angers, Maine-et-Loire, France

and more 10 locations

Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge

First Posted Date
2022-06-14
Last Posted Date
2024-07-08
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
45
Registration Number
NCT05418049
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.

Phase 4
Completed
Conditions
Addiction Opiate
Interventions
Drug: Baclofen
Drug: Vitamin D3
First Posted Date
2021-12-17
Last Posted Date
2024-11-18
Lead Sponsor
Imperial College London
Target Recruit Count
16
Registration Number
NCT05161351
Locations
🇬🇧

Imperial College Healthcare Trust, London, United Kingdom

Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients

Not Applicable
Terminated
Conditions
Cirrhosis
Interventions
Drug: Orphenadrine
Drug: Baclofen
First Posted Date
2020-08-12
Last Posted Date
2022-04-29
Lead Sponsor
Mansoura University
Target Recruit Count
5
Registration Number
NCT04509336
Locations
🇪🇬

Tanta University Hospitals, Tanta, Egypt

Effects of Baclofen on Presynaptic Inhibition in Humans

Phase 2
Withdrawn
Conditions
Spasticity, Muscle
Spinal Cord Injuries
Interventions
Drug: Baclofen
First Posted Date
2020-07-15
Last Posted Date
2022-04-07
Lead Sponsor
University of Alberta
Registration Number
NCT04471714
Locations
🇨🇦

524 HMRC, University of Alberta, Edmonton, Alberta, Canada

The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex

First Posted Date
2019-03-04
Last Posted Date
2021-06-18
Lead Sponsor
Mustafa Kemal University
Target Recruit Count
29
Registration Number
NCT03860662
Locations
🇹🇷

Hatay Mustafa Kemal University, Hatay, Turkey

A Placebo Controlled Trial With Baclofen for the Treatment of GERD Patients With Incomplete PPI Response

Not Applicable
Completed
Conditions
Gastro Esophageal Reflux
Interventions
Drug: Baclofen
Other: Placebos
First Posted Date
2019-02-08
Last Posted Date
2019-02-08
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
60
Registration Number
NCT03835442

Treatment of Chemotherapy-related Hiccups With Baclofen

Phase 4
Conditions
Hiccup
Interventions
Drug: Methoxyclopramide
Drug: Baclofen
First Posted Date
2018-12-19
Last Posted Date
2018-12-19
Lead Sponsor
Second Affiliated Hospital of Nanchang University
Target Recruit Count
120
Registration Number
NCT03778281
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