Mercaptopurine

Generic Name
Mercaptopurine
Brand Names
Purixan, Xaluprine (previously Mercaptopurine Nova Laboratories)
Drug Type
Small Molecule
Chemical Formula
C5H4N4S
CAS Number
50-44-2
Unique Ingredient Identifier
PKK6MUZ20G
Background

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Associated Conditions
Acute Lymphoblastic Leukaemias (ALL), Acute Promyelocytic Leukemia, Autoimmune Hepatitis, Crohn's Disease (CD), Lymphoblastic Lymphoma, Ulcerative Colitis
Associated Therapies
-

CINJALL: Treatment for Children With Acute Lymphocytic Leukemia

First Posted Date
2005-09-15
Last Posted Date
2014-06-09
Lead Sponsor
Rutgers, The State University of New Jersey
Target Recruit Count
60
Registration Number
NCT00176462
Locations
🇺🇸

Jersey Shore University Medical Center, Neptune, New Jersey, United States

🇺🇸

Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

Applying Pediatric Regimens to Younger Adult Patients With Acute Lymphoblastic Leukemia (ALL)

First Posted Date
2005-08-17
Last Posted Date
2008-11-14
Lead Sponsor
Japan Adult Leukemia Study Group
Target Recruit Count
120
Registration Number
NCT00131053
Locations
🇯🇵

Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan

High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL)

First Posted Date
2005-08-17
Last Posted Date
2008-11-14
Lead Sponsor
Japan Adult Leukemia Study Group
Target Recruit Count
240
Registration Number
NCT00131027
Locations
🇯🇵

Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan

S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

First Posted Date
2005-05-04
Last Posted Date
2015-03-25
Lead Sponsor
SWOG Cancer Research Network
Target Recruit Count
79
Registration Number
NCT00109837
Locations
🇺🇸

Providence Saint Joseph Medical Center - Burbank, Burbank, California, United States

🇺🇸

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg, South Carolina, United States

🇺🇸

Minor and James Medical, PLLC, Seattle, Washington, United States

and more 75 locations

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

First Posted Date
2005-02-08
Last Posted Date
2021-06-14
Lead Sponsor
Children's Oncology Group
Target Recruit Count
5377
Registration Number
NCT00103285
Locations
🇺🇸

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, United States

🇺🇸

Driscoll Children's Hospital, Corpus Christi, Texas, United States

🇨🇦

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec, Canada

and more 233 locations

Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes

First Posted Date
2004-11-09
Last Posted Date
2017-03-21
Lead Sponsor
Children's Oncology Group
Target Recruit Count
168
Registration Number
NCT00096135
Locations
🇺🇸

CancerCare of Maine at Eastern Maine Medical Center, Bangor, Maine, United States

🇺🇸

Childrens Hospital Los Angeles, Los Angeles, California, United States

🇺🇸

Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, California, United States

and more 150 locations

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia

First Posted Date
2004-09-13
Last Posted Date
2014-07-25
Lead Sponsor
Children's Oncology Group
Target Recruit Count
59
Registration Number
NCT00003671
Locations
🇺🇸

Cook Children's Medical Center - Fort Worth, Fort Worth, Texas, United States

🇺🇸

West Virginia University Hospitals, Morgantown, West Virginia, United States

🇺🇸

Madigan Army Medical Center, Tacoma, Washington, United States

and more 54 locations

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

First Posted Date
2004-09-01
Last Posted Date
2017-02-09
Lead Sponsor
Children's Oncology Group
Target Recruit Count
1970
Registration Number
NCT00002744
Locations
🇺🇸

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States

🇺🇸

Children's Hospital of Columbus, Columbus, Ohio, United States

🇺🇸

Children's Hospital and Medical Center - Seattle, Seattle, Washington, United States

and more 31 locations

Alemtuzumab With or Without Methotrexate and Mercaptopurine in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia

First Posted Date
2004-08-05
Last Posted Date
2013-06-05
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
25
Registration Number
NCT00089349
Locations
🇺🇸

COG Phase I Consortium, Arcadia, California, United States

SWOG-9400 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic Leukemia

Phase 2
Completed
Conditions
First Posted Date
2004-07-29
Last Posted Date
2015-03-06
Lead Sponsor
SWOG Cancer Research Network
Target Recruit Count
50
Registration Number
NCT00002665
Locations
🇺🇸

CCOP - Dayton, Kettering, Ohio, United States

🇺🇸

Boston Medical Center, Boston, Massachusetts, United States

🇺🇸

Cleveland Clinic Cancer Center, Cleveland, Ohio, United States

and more 80 locations
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