Mercaptopurine

Generic Name
Mercaptopurine
Brand Names
Purixan, Xaluprine (previously Mercaptopurine Nova Laboratories)
Drug Type
Small Molecule
Chemical Formula
C5H4N4S
CAS Number
50-44-2
Unique Ingredient Identifier
PKK6MUZ20G
Background

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Associated Conditions
Acute Lymphoblastic Leukaemias (ALL), Acute Promyelocytic Leukemia, Autoimmune Hepatitis, Crohn's Disease (CD), Lymphoblastic Lymphoma, Ulcerative Colitis
Associated Therapies
-

Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

First Posted Date
2014-12-01
Last Posted Date
2024-07-16
Lead Sponsor
Amgen
Target Recruit Count
130
Registration Number
NCT02303821
Locations
🇺🇸

Childrens Healthcare of Atlanta, Egleston, Atlanta, Georgia, United States

🇺🇸

West Virginia University Medicine Childrens, Morgantown, West Virginia, United States

🇹🇷

Medical Park Bahcelievler Hastanesi, Istanbul, Turkey

and more 116 locations

Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults

First Posted Date
2014-08-29
Last Posted Date
2019-11-26
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
19
Registration Number
NCT02228772
Locations
🇺🇸

Dana Farber Cancer Institute, Boston, Massachusetts, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis

First Posted Date
2014-07-31
Last Posted Date
2023-03-23
Lead Sponsor
North American Consortium for Histiocytosis
Target Recruit Count
1400
Registration Number
NCT02205762
Locations
🇺🇸

Children's Medical Center Dallas, UT Southwestern, Dallas, Texas, United States

🇺🇸

Children's Hospital of Los Angeles, Los Angeles, California, United States

🇺🇸

Hackensack University Medical Center, Hackensack, New Jersey, United States

and more 35 locations

A Study for Improving the Outcome of Childhood Acute Promyeloid Leukemia

First Posted Date
2014-07-25
Last Posted Date
2022-05-10
Lead Sponsor
South China Children's Leukemia Group
Target Recruit Count
176
Registration Number
NCT02200978
Locations
🇨🇳

The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy

First Posted Date
2014-06-27
Last Posted Date
2022-08-03
Lead Sponsor
Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Target Recruit Count
211
Registration Number
NCT02177071
Locations
🇦🇺

St Vincent Hospital, Melbourne, Australia

🇫🇷

Chu Clermont-Ferrand, Clermont-ferrand, Auvergne Rhone Alpes, France

🇫🇷

CHU LYON, Pierre Benite, Auvergne Rhone Alpes, France

and more 24 locations
© Copyright 2024. All Rights Reserved by MedPath