Octafluoropropane
- Generic Name
- Octafluoropropane
- Brand Names
- Definity, Luminity, Optison
- Drug Type
- Small Molecule
- Chemical Formula
- C3F8
- CAS Number
- 76-19-7
- Unique Ingredient Identifier
- CK0N3WH0SR
- Background
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
- Indication
Used as an ultrasound contrast imaging in cardiology and radiology.
- Associated Conditions
- -
- Associated Therapies
- -
Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Locally Advanced Breast Cancer-Phase II
- Conditions
- Breast Cancer
- Interventions
- Drug: DefinityDevice: Sonalleve Focused Ultrasound Device
- First Posted Date
- 2023-12-29
- Last Posted Date
- 2023-12-29
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 200
- Registration Number
- NCT06185972
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
A Study of Renal Microvessel Imaging for Chronic Kidney Disease
- Conditions
- Chronic Kidney DiseasesHealthy
- Interventions
- Drug: DefinityDiagnostic Test: Super-resolution ultrasound imaging
- First Posted Date
- 2023-03-10
- Last Posted Date
- 2024-10-17
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 186
- Registration Number
- NCT05764642
- Locations
- 🇺🇸
Mayo Clinic Minnesota, Rochester, Minnesota, United States
MRI-Guided Focused Ultrasound Radiosensitization for Patients With Malignant Melanoma and Non Melanoma Skin Cancer
- Conditions
- Melanoma
- Interventions
- Drug: DefinityDevice: Sonalleve Focused Ultrasound Device
- First Posted Date
- 2022-11-17
- Last Posted Date
- 2023-12-15
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 20
- Registration Number
- NCT05620290
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema
- First Posted Date
- 2022-11-14
- Last Posted Date
- 2024-08-21
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 10
- Registration Number
- NCT05613946
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Pancreas Ultrasound Imaging in type1 Diabetes
- Conditions
- Type1diabetesInsulitisPancreas Inflamed
- Interventions
- First Posted Date
- 2022-08-01
- Last Posted Date
- 2024-09-30
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 50
- Registration Number
- NCT05482321
- Locations
- 🇺🇸
University of Colorado Anschutz, Barbara Davis Center, Aurora, Colorado, United States
Diagnosing Compartment Syndrome With SHAPE vs Elastography
- First Posted Date
- 2022-02-21
- Last Posted Date
- 2023-12-12
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 15
- Registration Number
- NCT05247541
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Contrast Enhanced Ultrasound for Renal Obstruction
- Conditions
- Renal ObstructionKidney; Obstruction
- Interventions
- First Posted Date
- 2021-10-25
- Last Posted Date
- 2025-01-08
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 10
- Registration Number
- NCT05090800
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients With Head and Neck Cancer
- Conditions
- Head and Neck Cancer
- Interventions
- Drug: DEFINITYDevice: Sonalleve Focused Ultrasound Device
- First Posted Date
- 2020-06-16
- Last Posted Date
- 2023-12-13
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 20
- Registration Number
- NCT04431648
- Locations
- 🇨🇦
Gregory J Czarnota, Toronto, Ontario, Canada
3-D Super Resolution Ultrasound Microvascular Imaging
- Conditions
- Breast CancerThyroid Cancer
- Interventions
- Drug: DefinityDevice: Acoustic Angiography
- First Posted Date
- 2019-10-23
- Last Posted Date
- 2024-11-06
- Lead Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Target Recruit Count
- 27
- Registration Number
- NCT04136912
- Locations
- 🇺🇸
Univeristy of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States
Non-invasive Blood-brain Barrier Opening in Alzheimer's Disease Patients Using Focused Ultrasound
- Conditions
- Alzheimer Disease
- Interventions
- Device: Neuronavigation-guided single-element focused ultrasound transducerDrug: DefinityOther: Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agentsOther: Positron Emission Tomography (PET)Other: Amyvid
- First Posted Date
- 2019-10-08
- Last Posted Date
- 2024-08-26
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 6
- Registration Number
- NCT04118764
- Locations
- 🇺🇸
Columbia University Irving Medical Center/NYPH, New York, New York, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.