Octafluoropropane

Generic Name: Octafluoropropane

Brand Names: Definity, Luminity, Optison

Drug Type: Small Molecule

Chemical Formula: C_₃F_₈

CAS Number: 76-19-7

Unique Ingredient Identifier: CK0N3WH0SR

Background: Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.

Indication: Used as an ultrasound contrast imaging in cardiology and radiology.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Pilot 3D Contrast-Enhanced Ultrasound Imaging to Predict Treatment Response in Liver Metastases

Not Applicable

Completed

Conditions: Colon Cancer
Liver Metastases

Interventions: Procedure: Dynamic contrast-enhanced ultrasound imaging
Device: Optical Tracking Device
Device: Electromagnetic Tracking Device
Drug: Perflutren

First Posted Date: 2012-06-29

Last Posted Date: 2022-06-10

Lead Sponsor: Stanford University

Target Recruit Count: 34

Registration Number: NCT01631318

Locations: 🇺🇸
Stanford University, Stanford, California, United States

Monitoring Renal Blood Flow With Contrast Enhanced Ultrasound During Coronary Angiogram

Not Applicable

Conditions: Contrast Induced Acute Kidney Injury

Interventions: Drug: perflutren

First Posted Date: 2012-03-05

Last Posted Date: 2013-12-19

Lead Sponsor: University of Virginia

Target Recruit Count: 150

Registration Number: NCT01544036

Locations: 🇺🇸
University of Virginia Health System, Charlottesville, Virginia, United States

Efficacy of Ultrasound Contrast Agent to Assess Renal Masses

Phase 2

Completed

Conditions: Renal Cell Carcinoma

Interventions: Drug: Definity

First Posted Date: 2010-02-04

Last Posted Date: 2016-03-08

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 167

Registration Number: NCT01062178

Locations: 🇨🇦
Toronto General Hospital, Toronto, Ontario, Canada

Evaluation of Contrast-Enhanced Ultrasound to Detect Endoleaks After Endovascular Aortic Aneurysm Repair

Completed

Conditions: Endoleaks

First Posted Date: 2009-10-30

Last Posted Date: 2024-04-12

Lead Sponsor: E. Peden, MD

Target Recruit Count: 20

Registration Number: NCT01005212

Locations: 🇺🇸
Houston Methodist Hospital; Department of Cardiovascular Surgery, Houston, Texas, United States
🇺🇸
Houston Methodist Hospital; Department of Cardiovascualr Surgery, Houston, Texas, United States

A Study of Commercial DEFINITY® to Monitor the Effects of the Heart's Pulmonary Artery Pressure

Phase 4

Completed

Conditions: Pulmonary Heart Disease

Interventions: Drug: Definity

First Posted Date: 2009-06-11

Last Posted Date: 2020-11-24

Lead Sponsor: Lantheus Medical Imaging

Target Recruit Count: 32

Registration Number: NCT00918866

Locations: 🇺🇸
Cardiovascular Consultants, Kansas City, Missouri, United States
🇺🇸
The Cleveland Clinic Foundation, Cleveland, Ohio, United States
🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States

and more 5 locations

Contrast-Enhanced Ultrasonography in Diagnosing Early-Stage Ovarian Cancer in Patients With an Adnexal Mass Undergoing Surgery to Remove the Ovary

Phase 1

Completed

Conditions: Ovarian Cancer

Interventions: Drug: Definity
Other: medical chart review

First Posted Date: 2008-02-29

Last Posted Date: 2017-04-18

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 67

Registration Number: NCT00626873

Locations: 🇺🇸
Vanderbilt-Ingram Cancer Center at Franklin, Nashville, Tennessee, United States
🇺🇸
Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville, Tennessee, United States
🇺🇸
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States