Mefloquine
- Generic Name
- Mefloquine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C17H16F6N2O
- CAS Number
- 53230-10-7
- Unique Ingredient Identifier
- TML814419R
- Background
Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortality; 90% of deaths from malaria occur in ...
- Indication
Mefloquine is indicated for the treatment of mild to moderate cases of malaria caused by Plasmodium falciparum and Plasmodium vivax. It is effective against chloroquine-resistant forms of Plasmodium falciparum. Mefloquine is also indicated for the prophylaxis of malaria caused by Plasmodium falciparum and Plasmodium vivax, including chloroquine-resistant for...
- Associated Conditions
- Malaria caused by Plasmodium falciparum, Malaria caused by plasmodium vivax
- Associated Therapies
- -
A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19
- First Posted Date
- 2020-04-15
- Last Posted Date
- 2021-01-27
- Lead Sponsor
- Burnasyan Federal Medical Biophysical Center
- Target Recruit Count
- 320
- Registration Number
- NCT04347031
- Locations
- 🇷🇺
Burnasyan Federal Medical Biophysical Center FMBA of Russia, Moscow, Russian Federation
A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients
- Conditions
- Interventions
- First Posted Date
- 2015-08-14
- Last Posted Date
- 2017-12-11
- Lead Sponsor
- ORIYOMI OMOTOYOSI AKINYOTU
- Target Recruit Count
- 142
- Registration Number
- NCT02524444
- Locations
- 🇳🇬
University College Hospital, Ibadan, OYO State, Nigeria
An Evaluation of Weekly Tafenoquine
- Conditions
- Interventions
- First Posted Date
- 2015-07-02
- Last Posted Date
- 2017-05-30
- Target Recruit Count
- 306
- Registration Number
- NCT02488980
Pharmacokinetic and Pharmacodynamic Study of Mefloquine and Dihydroartemisinin-Piperaquine in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-12-24
- Last Posted Date
- 2015-11-03
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 16
- Registration Number
- NCT02324738
- Locations
- 🇹ðŸ‡
Faculty of Tropical Medicine, Bangkok, Thailand
Assessment of Artesunate/Mefloquine in the Peruvian Amazon
- First Posted Date
- 2014-03-12
- Last Posted Date
- 2021-04-29
- Lead Sponsor
- Instituto Nacional de Salud. Peru
- Target Recruit Count
- 45
- Registration Number
- NCT02084602
- Locations
- 🇵🇪
NAMRU 6, Iquitos, Loreto, Peru
In Vivo and In Vitro Efficacy of Artemisinin Combination Therapy
- Conditions
- Interventions
- First Posted Date
- 2013-11-06
- Last Posted Date
- 2017-05-11
- Target Recruit Count
- 118
- Registration Number
- NCT01976780
- Locations
- 🇰🇪
Walter Reed Project, Kombewa Clinic, Kisumu, Kenya
Efficacy of Artesunate-Mefloquine Combination Therapy in Trat Province, Thailand
- Conditions
- Interventions
- First Posted Date
- 2012-08-07
- Last Posted Date
- 2012-08-07
- Target Recruit Count
- 13
- Registration Number
- NCT01659281
- Locations
- 🇹ðŸ‡
Vector Borne Diseases Control Units (VBDC, malaria clinics), Borai, Khaosaming and Muang districts, Trat, Thailand
Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy
- Conditions
- Interventions
- First Posted Date
- 2011-09-08
- Last Posted Date
- 2024-07-29
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 144
- Registration Number
- NCT01430351
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Activity of Mefloquine Against Urinary Schistosomiasis
- First Posted Date
- 2010-05-28
- Last Posted Date
- 2013-01-24
- Lead Sponsor
- Albert Schweitzer Hospital
- Target Recruit Count
- 65
- Registration Number
- NCT01132248
- Locations
- 🇬🇦
Albert Schweitzer Hospital, Lambarene, Gabon
Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine
- Conditions
- Interventions
- First Posted Date
- 2009-09-03
- Last Posted Date
- 2013-01-23
- Lead Sponsor
- Institut de Recherche pour le Developpement
- Target Recruit Count
- 430
- Registration Number
- NCT00970879
- Locations
- 🇧🇯
Hôpital de zone de Suru Lere, Cotonou, Benin
🇧🇯Hôpital d'Instruction des Armées Camp Guézo, Cotonou, Benin
🇧🇯Clinique Louis Pasteur, Porto-Novo, Benin
Drug Development Updates
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