Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering. It was developed in an effort to create an estrogen with greater oral bioavailability. These properties were achieved by the substitution of an ethinyl group at carbon 17 of estradiol. Ethinylestradiol soon replaced mestranol in contraceptive pills.
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Ethinylestradiol is combined with other drugs for use as a contraceptive, premenstrual dysphoric disorder, moderate acne, moderate to severe vasomotor symptoms of menopause, prevention of postmenopausal osteoporosis.
Catholic university of Sacred Heart, Rome, Italy
1220.56.1 Boehringer Ingelheim Investigational Site, Biberach, Germany
Sydney centre for Reproductive Health Research, FPNSW, Sydney, New South Wales, Australia
1245.41.1 Boehringer Ingelheim Investigational Site, Biberach, Germany
Tehran University of Medical Sciences-BASIR center, Tehran, Iran, Islamic Republic of
GSK Investigational Site, Fargo, North Dakota, United States
Royal University Hospital, Saskatoon, Saskatchewan, Canada
GSK Investigational Site, Miramar, Florida, United States
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