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Thiopental

Generic Name
Thiopental
Drug Type
Small Molecule
Chemical Formula
C11H18N2O2S
CAS Number
76-75-5
Unique Ingredient Identifier
JI8Z5M7NA3
Background

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)

Indication

For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders.

Associated Conditions
Seizures

Prevention of Complications of Eye Surgery

Phase 2
Completed
Conditions
Strabismus
First Posted Date
2007-05-25
Last Posted Date
2007-05-25
Lead Sponsor
Isfahan University of Medical Sciences
Target Recruit Count
300
Registration Number
NCT00478907
Locations
🇮🇷

Feiz Hospital, Tehran, Isfahan, Iran, Islamic Republic of

Effect of Affective Content on Drug Induced Amnesia of Episodic Memory

Phase 1
Completed
Conditions
Memory Losses
Amnesia-Memory Loss
Interventions
First Posted Date
2005-09-02
Last Posted Date
2015-12-24
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
79
Registration Number
NCT00142493
Locations
🇺🇸

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

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