A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Thalidomide is primarily used for the acute treatment and maintenance therapy to prevent and suppress the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL).
Clinica di ematologia ospedali riuniti ancona università politecnica delle marche, Ancona, Italy
Illinois CancerCare-Havana, Havana, Illinois, United States
Mason District Hospital, Havana, Illinois, United States
Marietta Memorial Hospital, Marietta, Ohio, United States
Trondheim University Hospital, Trondheim, Norway
Herlev University Hospital, Herlev, Denmark
Odense University Hospital, Odense, Denmark
Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
University of Arkansas for Medical Sciences/Myeloma Institute, Little Rock, Arkansas, United States
Weill Medical College of Cornell University, New York, New York, United States
Weill Medical College of Cornell University, New York, New York, United States
Beth Israel Medical Center, New York, New York, United States
UT MD Anderson Cancer Center, Houston, Texas, United States
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.