A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Thalidomide is primarily used for the acute treatment and maintenance therapy to prevent and suppress the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL).
Washington University School of Medicine, St. Louis, Missouri, United States
AULSS 2 Feltre, Feltre, Italy
Ospedale Ca Foncello, Treviso, Italy
Ospedale dell'Angelo di Mestre, Mestre, Italy
Clinica Medica 3, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, United States
Helen DeVos Children's Hospital, Grand Rapids, Michigan, United States
AOU di Bologna Policlinico S.Orsola-Malpighi, UO di Ematologia, Bologna, Italy
Weill Cornell Medical College, New York, New York, United States
Banner Sun Health Research Institute, Sun City, Arizona, United States
Mayo Clinic in Arizona, Scottsdale, Arizona, United States
Medical University of South Carolina, Charleston, South Carolina, United States
Mayo Clinic, Rochester, Minnesota, United States
Harborview Medical Center, Seattle, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Group Health Central Hospital, Seattle, Washington, United States
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