尼扎替丁 (Axid)

概览

Nizatidine is an H2 receptor antagonist used to treat GERD and a variety of ulcers.

作用机制

Nizatidine competes with histamine for binding at the H-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.

适应症

For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.

• Duodenal Ulcer
• Esophagitis
• Gastric Ulcer
• Gastro-esophageal Reflux Disease (GERD)
• Helicobacter Pylori Infection
• Peptic Ulcer Disease
• Stress Ulcers