Venetoclax

Generic Name: Venetoclax

Brand Names: Venclexta, Venclyxto

Drug Type: Small Molecule

Chemical Formula: C_₄₅H_₅₀ClN_₇O_₇S

CAS Number: 1257044-40-8

Unique Ingredient Identifier: N54AIC43PW

Background: Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 . Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic lymphoma . CLL is the most prevalent leu...

Indication: 本品与阿扎胞苷联合用于治疗因合并症不适合接受强诱导化疗，或者年龄75岁及以上的新诊断的成人急性髓系白血病患者。

Associated Conditions: Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Associated Therapies: -

Clinical Trials

Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma

Phase 1

Recruiting

Conditions: Mantle Cell Lymphoma

Interventions: Drug: Venetoclax
Drug: Lenalidomide
Drug: Rituximab

First Posted Date: 2018-05-14

Last Posted Date: 2024-07-05

Lead Sponsor: City of Hope Medical Center

Target Recruit Count: 28

Registration Number: NCT03523975

Locations: 🇺🇸
City of Hope Medical center, Duarte, California, United States
🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
🇺🇸
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Venetoclax and Ibrutinib in Treating in Participants With Chronic Lymphocytic Leukemia and Ibrutinib Resistance Mutations

Phase 2

Active, not recruiting

Conditions: Chronic Lymphocytic Leukemia
Ibrutinib Resistance

Interventions: Drug: Ibrutinib
Other: Laboratory Biomarker Analysis
Drug: Venetoclax

First Posted Date: 2018-05-01

Last Posted Date: 2023-11-08

Lead Sponsor: Ohio State University Comprehensive Cancer Center

Target Recruit Count: 28

Registration Number: NCT03513562

Locations: 🇺🇸
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Venetoclax, Lenalidomide and Rituximab in Patients With Relapsed/Refractory Mantle Cell Lymphoma

Phase 1

Conditions: Relapsed Non Hodgkin Lymphoma

Interventions: Drug: Venetoclax

First Posted Date: 2018-04-23

Last Posted Date: 2021-10-13

Lead Sponsor: Nordic Lymphoma Group

Target Recruit Count: 59

Registration Number: NCT03505944

Locations: 🇫🇮
Oulu University Hospital, Oulu, Finland
🇳🇴
Oslo University Hospital, Oslo, Norway
🇸🇪
Uppsla Academic Hospital, Uppsala, Sweden

and more 14 locations

Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia

Phase 1

Active, not recruiting

Conditions: Recurrent Adult Lymphoblastic Lymphoma
Recurrent B Acute Lymphoblastic Leukemia
Recurrent B Lymphoblastic Lymphoma
Recurrent T Acute Lymphoblastic Leukemia
Recurrent T Lymphoblastic Lymphoma
Refractory B Acute Lymphoblastic Leukemia
Refractory B Lymphoblastic Lymphoma
Refractory T Acute Lymphoblastic Leukemia
Refractory T Lymphoblastic Lymphoma

Interventions: Procedure: Biospecimen Collection
Procedure: Computed Tomography
Procedure: Lumbar Puncture
Procedure: Positron Emission Tomography
Drug: Venetoclax
Drug: Vincristine Liposomal
Drug: Vincristine Sulfate

First Posted Date: 2018-04-20

Last Posted Date: 2024-11-06

Lead Sponsor: ECOG-ACRIN Cancer Research Group

Target Recruit Count: 74

Registration Number: NCT03504644

Locations: 🇺🇸
OSF Saint Francis Medical Center, Peoria, Illinois, United States
🇺🇸
Illinois CancerCare-Peru, Peru, Illinois, United States
🇺🇸
Valley Radiation Oncology, Peru, Illinois, United States

and more 167 locations

A Study Of The Selective PKC-β Inhibitor MS- 553

Phase 1

Terminated

Conditions: Small Lymphocytic Lymphoma
Aggressive Lymphoma
Chronic Lymphocytic Leukemia

Interventions: Drug: MS-553
Drug: acalabrutinib
Drug: venetoclax
Drug: Rituximab
Drug: obinutuzumab

First Posted Date: 2018-04-10

Last Posted Date: 2024-07-18

Lead Sponsor: MingSight Pharmaceuticals, Inc

Target Recruit Count: 63

Registration Number: NCT03492125

Locations: 🇺🇸
University Of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
🇺🇸
Columbia University, Herbert Irving Comprehensive Cancer Center, New York, New York, United States
🇺🇸
MD Anderson Cancer Center, Department of Leukemia, Houston, Texas, United States

and more 2 locations

Study of Venetoclax, a BCL2 Antagonist, for Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Phase 1

Active, not recruiting

Conditions: Blastic Plasmacytoid Dendritic Cell Neoplasm

Interventions: Drug: Venetoclax

First Posted Date: 2018-04-02

Last Posted Date: 2024-02-13

Lead Sponsor: Dana-Farber Cancer Institute

Target Recruit Count: 5

Registration Number: NCT03485547

Locations: 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
🇺🇸
Dana Farber Cancer Institute, Boston, Massachusetts, United States

A Study of Venetoclax and Dinaciclib (MK7965) in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Phase 1

Terminated

Conditions: Cancer - Acute Myeloid Leukemia

Interventions: Drug: Venetoclax
Drug: Dinaciclib

First Posted Date: 2018-03-30

Last Posted Date: 2022-12-30

Lead Sponsor: AbbVie

Target Recruit Count: 48

Registration Number: NCT03484520

Locations: 🇺🇸
David Geffen School of Medicin /ID# 200015, Los Angeles, California, United States
🇺🇸
The Ohio State University /ID# 200668, Columbus, Ohio, United States
🇦🇺
Gold coast University Hospital /ID# 202759, SouthPort, Queensland, Australia

and more 10 locations

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

Phase 1

Recruiting

Conditions: Hematopoietic and Lymphoid System Neoplasm
Refractory Acute Myeloid Leukemia
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Myeloproliferative Neoplasm
Recurrent Acute Myeloid Leukemia

Interventions: Drug: Azacitidine
Drug: Ivosidenib
Drug: Venetoclax

First Posted Date: 2018-03-20

Last Posted Date: 2024-07-26

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 96

Registration Number: NCT03471260

Locations: 🇺🇸
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States

and more 1 locations

A Study of Venetoclax and Rituximab/Hyaluronidase Human in Relapsed/Refractory CLL

Phase 2

Active, not recruiting

Conditions: Chronic Lymphocytic Leukemia

Interventions: Drug: Venetoclax
Drug: Rituximab
Drug: Rituximab/Hyaluronidase Human

First Posted Date: 2018-03-16

Last Posted Date: 2024-10-30

Lead Sponsor: Georgetown University

Target Recruit Count: 25

Registration Number: NCT03467867

Locations: 🇺🇸
Georgetown University Medical Center, Washington, District of Columbia, United States
🇺🇸
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States

A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Phase 3

Active, not recruiting

Conditions: Leukemia, Lymphocytic, Chronic, B-Cell

Interventions: Drug: Ibrutinib
Drug: Chlorambucil
Drug: Venetoclax
Drug: Obinutuzumab
Drug: Ibrutinib (as Subsequent Therapy)

First Posted Date: 2018-03-12

Last Posted Date: 2024-12-09

Lead Sponsor: Janssen Research & Development, LLC

Target Recruit Count: 211

Registration Number: NCT03462719

Locations: 🇨🇦
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta, Canada
🇺🇸
Norton Cancer Institute, Louisville, Kentucky, United States
🇺🇸
John Theurer Cancer Center, Hackensack, New Jersey, United States

and more 84 locations

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