Botulinum toxin type A

Generic Name: Botulinum toxin type A

Brand Names: Botox, Botox Cosmetic, Dysport, Jeuveau, Xeomin, Nuceiva

Drug Type: Biotech

Chemical Formula: -

CAS Number: 93384-43-1

Unique Ingredient Identifier: 0A6JH35GMQ

Background: In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperfections, muscle spasms, and other condit...

Indication: Botulinum toxin A is indicated for a variety of conditions, depending on the preparations. Cosmetically, it is used for the treatment of facial fine lines and wrinkles, specifically for upper facial rhytides, including forehead, lateral canthus, and glabellar lines.
...

Associated Conditions: Bladder pain, Blepharospasm, Cervical Dystonia, Chronic Migraine, Diabetic Neuropathies, Epicondylitis, Equinus deformity of foot, acquired, Facial Skin Wrinkles, Glabellar Frown Lines (GL), Lower Limb Spasticity, Myofascial Pain Syndrome, Neurogenic Detrusor Overactivity, Neurogenic Thoracic Outlet Syndrome, Overactive Bladder Syndrome (OABS), Post Stroke Pain, Postherpetic Neuralgia, Sialorrhea, Spasticity, Spinal Cord Injuries, Strabismus, TMJ Disorders, Trigeminal Neuralgia (TN), Upper Limb Spasticity, Urinary Incontinence (UI), Hypertonicity disorders of the 7th nerve, Moderate Glabellar Frown Lines (GL), Severe Glabellar Frown Lines (GL), Severe axillary hyperhidrosis

Associated Therapies: -

Clinical Trials

Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache

Phase 3

Recruiting

Conditions: Cluster Headache

Interventions: Drug: placebo
Drug: Botulinum toxin type A

First Posted Date: 2019-05-10

Last Posted Date: 2024-11-19

Lead Sponsor: Norwegian University of Science and Technology

Target Recruit Count: 112

Registration Number: NCT03944876

Locations: 🇩🇪
Praxisklinik Ulmenhof, Hamburg, Germany
🇮🇹
Fondazione IRCCS Istituto Neurologico Carlo Besta (CBNI), Milano, Italy
🇳🇴
St Olavs Hospital, Trondheim, Norway

and more 2 locations

Dysport ® as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis

Phase 4

Recruiting

Conditions: Adolescent Idiopathic Scoliosis

Interventions: Drug: AbobotulinumtoxinA
Drug: Placebos
Device: Custom Thoracolumbosacral Orthosis

First Posted Date: 2019-05-02

Last Posted Date: 2024-12-20

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 90

Registration Number: NCT03935295

Locations: 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States

Abobotulinumtoxina Efficacy in Post-Traumatic Headache

Phase 4

Completed

Conditions: Post-Traumatic Headache

Interventions: Drug: Normal saline
Drug: AbobotulinumtoxinA

First Posted Date: 2019-04-26

Last Posted Date: 2019-04-26

Lead Sponsor: VA Greater Los Angeles Healthcare System

Target Recruit Count: 40

Registration Number: NCT03928496

Locations: 🇺🇸
VA Greater Los Angeles Healthcare System, Los Angeles, California, United States

Botulinum Toxin A & Weekly Serial Casting in ABI Inpatients With Lower Extremity Spasticity

Phase 2

Withdrawn

Conditions: Spastic Foot

Interventions: Drug: Botulinum toxin type A
Device: Serial Casting

First Posted Date: 2019-04-04

Last Posted Date: 2023-09-28

Lead Sponsor: Hamilton Health Sciences Corporation

Registration Number: NCT03903653

Efficacy and Safety Study of MT10109L in the Treatment of Glabella Line(Including a Preliminary Study to Evaluate Safety of MT10109L)

Phase 2

Completed

Conditions: Glabella Line Severity

Interventions: Drug: Botulinum Toxin Type A

First Posted Date: 2019-03-28

Last Posted Date: 2019-03-28

Lead Sponsor: Medy-Tox

Target Recruit Count: 168

Registration Number: NCT03894748

Locations: 🇰🇷
The Catholic University of Korea, St. Paul's Hospital, Seoul, Dongdaemun-gu, Korea, Republic of
🇰🇷
Inha University Hospital, Incheon, Jung-gu, Korea, Republic of
🇰🇷
Kyung Hee University Hospital at Gangdong, Seoul, Kangdong-gu, Korea, Republic of