Curcumin

Generic Name: Curcumin

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₀O_₆

CAS Number: 458-37-7

Unique Ingredient Identifier: IT942ZTH98

Background: Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities . Due to these properties, curcumin has been investigated for...

Indication: No approved therapeutic indications.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer

Phase 1

Completed

Conditions: Malignant Neoplasm
Pain
Bladder Spasm
Urinary Urgency

Interventions: Drug: Curcumin
Other: Laboratory Biomarker Analysis
Dietary Supplement: Piperine Extract (Standardized)
Other: Quality-of-Life Assessment

First Posted Date: 2015-11-06

Last Posted Date: 2024-11-08

Lead Sponsor: Mayo Clinic

Target Recruit Count: 9

Registration Number: NCT02598726

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Effect of Curcumin in Treatment of Squamous Cervical Intraepithelial Neoplasias (CINs)

Early Phase 1

Conditions: Cervical Intraepithelial Neoplasia

Interventions: Drug: Curcumin

First Posted Date: 2015-09-18

Last Posted Date: 2016-03-17

Lead Sponsor: Baylor Research Institute

Target Recruit Count: 14

Registration Number: NCT02554344

Locations: 🇺🇸
Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States

Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults With ADPKD

Phase 4

Completed

Conditions: Polycystic Kidney, Autosomal Dominant

Interventions: Other: Placebo
Drug: Curcumin

First Posted Date: 2015-07-10

Last Posted Date: 2022-03-03

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 68

Registration Number: NCT02494141

Locations: 🇺🇸
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients.

Phase 1

Completed

Conditions: Dentist-Patient Relations

Interventions: Drug: Chlorhexidine gluconate
Drug: DMSO + water
Drug: Curcumin
Device: LED
Drug: Surfactant

First Posted Date: 2015-01-13

Last Posted Date: 2015-01-13

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 24

Registration Number: NCT02337192

Locations: 🇧🇷
Vitor Hugo Panhóca, São Carlos, SP, Brazil

Study to See How Safe Curcumin is and How Well it Works When Used to Treat Mucositis in Patients Getting Chemotherapy

Phase 1

Terminated

Conditions: Mucositis

Interventions: Drug: Mouthwash-standard pharmacy preparation
Drug: Curcumin
Drug: Curcumin-MTD

First Posted Date: 2014-11-25

Last Posted Date: 2019-05-31

Lead Sponsor: Amy Beres

Target Recruit Count: 6

Registration Number: NCT02300727

Locations: 🇺🇸
Aurora BayCare Medical Center, Green Bay, Wisconsin, United States

Curcumin Addition to Antipsychotic Treatment in Chronic Schizophrenia Patients

Phase 4

Completed

Conditions: Chronic Schizophrenia

Interventions: Drug: Curcumin
Drug: placebo

First Posted Date: 2014-11-24

Last Posted Date: 2019-01-15

Lead Sponsor: Beersheva Mental Health Center

Target Recruit Count: 38

Registration Number: NCT02298985

Locations: 🇮🇱
Beersheva Mental Health Center, Beersheva, Israel
🇮🇱
Tirat Carmel Mental Health Center, Tirat Carmel, Israel

Curcumin Associated With Thiopurin in the Prevention of Post-op Recurrence in Crohn Disease

Phase 3

Completed

Conditions: Crohn's Disease

Interventions: Drug: Curcumin

First Posted Date: 2014-10-02

Last Posted Date: 2018-12-28

Lead Sponsor: University Hospital, Clermont-Ferrand

Target Recruit Count: 61

Registration Number: NCT02255370

Locations: 🇫🇷
CHU de Clermont-Ferrand, Clermont-Ferrand, France

Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia

Phase 1

Completed

Conditions: Schizophrenia
Cognition
Psychosis

Interventions: Drug: Placebo
Drug: Curcumin

First Posted Date: 2014-04-04

Last Posted Date: 2019-05-15

Lead Sponsor: VA Greater Los Angeles Healthcare System

Target Recruit Count: 39

Registration Number: NCT02104752

Locations: 🇺🇸
VA Greater Los Angeles, Los Angeles, California, United States

Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Phase 2

Completed

Conditions: Stage II Chronic Lymphocytic Leukemia
Contiguous Stage II Small Lymphocytic Lymphoma
Noncontiguous Stage II Small Lymphocytic Lymphoma
Stage 0 Chronic Lymphocytic Leukemia
Stage I Small Lymphocytic Lymphoma
Stage I Chronic Lymphocytic Leukemia

Interventions: Drug: curcumin
Dietary Supplement: cholecalciferol
Other: laboratory biomarker analysis
Other: pharmacological study

First Posted Date: 2014-04-01

Last Posted Date: 2024-04-12

Lead Sponsor: Paolo Caimi, MD

Target Recruit Count: 35

Registration Number: NCT02100423

Locations: 🇺🇸
Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Multicenter Study Comparing Taxotere Plus Curcumin Versus Taxotere Plus Placebo Combination in First-line Treatment of Prostate Cancer Metastatic Castration Resistant (CURTAXEL)

Phase 2

Terminated

Conditions: Prostate Cancer Metastatic Castration Resistant

Interventions: Drug: Placebo
Drug: Curcumin
Drug: Taxotere

First Posted Date: 2014-03-26

Last Posted Date: 2018-07-24

Lead Sponsor: Centre Jean Perrin

Target Recruit Count: 50

Registration Number: NCT02095717

Locations: 🇫🇷
Centre Hospitalier Emile Roux, Le Puy en velay, France
🇫🇷
Institut Jean Godinot, Reims, France
🇫🇷
Centre Jean Perrin, Clermont-Ferrand, France

and more 1 locations

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