Oxaliplatin
- Generic Name
- Oxaliplatin
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C8H14N2O4Pt
- CAS Number
- 61825-94-3
- Unique Ingredient Identifier
- 04ZR38536J
- Background
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemic...
- Indication
Oxaliplatin, in combination with infusional fluorouracil and leucovorin, is indicated for the treatment of advanced colorectal cancer and adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.
- Associated Conditions
- Advanced Colorectal Cancer, Stage III Colon Cancer
- Associated Therapies
- -
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-01-23
- Last Posted Date
- 2012-07-02
- Target Recruit Count
- 554
- Registration Number
- NCT00003287
- Locations
- 🇬🇷
University Hospital of Heraklion, Iraklion (Heraklion), Crete, Greece
🇫🇷Centre Hospitalier de Montlucon, Montlucon, France
🇫🇷Hopital Notre-Dame de Bon Secours, Metz, France
Gemcitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced or Metastatic Unresectable Pancreatic Adenocarcinoma
- Conditions
- Locations
- 🇫🇷
C.H.G. Beauvais, Beauvais, France
🇫🇷Hopital Saint Andre, Bordeaux, France
🇫🇷Centre Paul Papin, Angers, France
Docetaxel and Oxaliplatin in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer
- Conditions
- Locations
- 🇫🇷
C.H. Senlis, Senlis, France
🇫🇷Hopital Saint Antoine, Paris, France
🇫🇷Intercommunal Hospital, Montfermeil, France
Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-01-07
- Last Posted Date
- 2013-06-26
- Lead Sponsor
- Prologue Research International
- Registration Number
- NCT00017082
- Locations
- 🇺🇸
Comprehensive Cancer Care Specialists of Boca Raton, Boca Raton, Florida, United States
🇺🇸University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸Kentuckiana Cancer Institute, Louisville, Kentucky, United States
Fluorouracil and Leucovorin With or Without Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-01-07
- Last Posted Date
- 2013-06-26
- Lead Sponsor
- Prologue Research International
- Registration Number
- NCT00016198
- Locations
- 🇺🇸
South Shore Hematology Oncology Associates, P.C., Rockville Centre, New York, United States
🇺🇸Center for Hematology-Oncology, Boca Raton, Florida, United States
🇺🇸Pennsylvania Oncology Hematology Associates, Philadelphia, Pennsylvania, United States
Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors
- Conditions
- Interventions
- First Posted Date
- 2003-12-11
- Last Posted Date
- 2013-02-11
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 30
- Registration Number
- NCT00004242
- Locations
- 🇺🇸
NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York, New York, United States
🇺🇸Albert Einstein Comprehensive Cancer Center, Bronx, New York, United States
Irinotecan, Oxaliplatin, and Capecitabine in Treating Patients With Unresectable Solid Tumors
- First Posted Date
- 2003-12-11
- Last Posted Date
- 2013-06-06
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 84
- Registration Number
- NCT00074321
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Oxaliplatin in Treating Patients With Persistent or Recurrent Endometrial Cancer
- Conditions
- First Posted Date
- 2003-11-06
- Last Posted Date
- 2013-06-24
- Lead Sponsor
- Gynecologic Oncology Group
- Registration Number
- NCT00071929
- Locations
- 🇺🇸
Ireland Cancer Center, Cleveland, Ohio, United States
🇺🇸Mount Carmel West Hospital, Columbus, Ohio, United States
🇺🇸Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
Celecoxib, Leucovorin, Fluorouracil, and Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer
- Conditions
- Locations
- 🇫🇷
Hopital Tenon, Paris, France
Oxaliplatin and Fluorouracil in Treating Patients With Recurrent Ovarian Cancer
- Conditions
- First Posted Date
- 2003-11-04
- Last Posted Date
- 2014-06-24
- Lead Sponsor
- University of Leicester
- Registration Number
- NCT00004206
- Locations
- 🇬🇧
University Hospitals of Leicester, Leicester, England, United Kingdom
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.