Oxaliplatin

Generic Name
Oxaliplatin
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C8H14N2O4Pt
CAS Number
61825-94-3
Unique Ingredient Identifier
04ZR38536J
Background

Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking. However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects. The DACH moiety also prevents cross-resistance with cisplatin and carboplatin.

Although oxaliplatin has been investigated as a monotherapy, it is typically administered in combination with fluorouracil and leucovorin, known as the FOLFOX regimen, for the treatment of colorectal cancer. This is an effective combination treatment both as a first-line treatment and in patients refractory to an initial fluorouracil and leucovorin combination. Ongoing trials have also shown promising results for oxaliplatin use in nonHodgkinโ€™s lymphoma, breast cancer, mesothelioma, and non-small cell lung cancer.

Oxaliplatin was approved by the FDA on January 9, 2004 and is currently marketed by Sanofi-Aventis under the trademark Eloxatinยฎ.

Indication

Oxaliplatin, in combination with infusional fluorouracil and leucovorin, is indicated for the treatment of advanced colorectal cancer and adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.

Associated Conditions
Advanced Colorectal Cancer, Stage III Colon Cancer
Associated Therapies
-

Gemcitabine Plus Oxaliplatin in Treating Patients With Refractory Locally Advanced or Metastatic Pancreatic Cancer

First Posted Date
2004-05-25
Last Posted Date
2016-07-14
Lead Sponsor
Alliance for Clinical Trials in Oncology
Target Recruit Count
59
Registration Number
NCT00004190
Locations
๐Ÿ‡บ๐Ÿ‡ธ

CCOP - Scottsdale Oncology Program, Scottsdale, Arizona, United States

๐Ÿ‡บ๐Ÿ‡ธ

CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska, United States

๐Ÿ‡บ๐Ÿ‡ธ

CCOP - Sioux Community Cancer Consortium, Sioux Falls, South Dakota, United States

and more 16 locations

Paclitaxel and Oxaliplatin in Treating Patients With Recurrent or Advanced Non-small Cell Lung Cancer

Phase 2
Completed
Conditions
Interventions
First Posted Date
2004-05-21
Last Posted Date
2013-02-11
Lead Sponsor
University of Chicago
Target Recruit Count
38
Registration Number
NCT00004126
Locations
๐Ÿ‡บ๐Ÿ‡ธ

University of Chicago Cancer Research Center, Chicago, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

University of Illinois at Chicago, Chicago, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

Louis A. Weiss Memorial Hospital, Chicago, Illinois, United States

and more 8 locations

Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer

First Posted Date
2004-04-27
Last Posted Date
2013-06-26
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
36
Registration Number
NCT00003427
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

First Posted Date
2004-04-14
Last Posted Date
2016-07-06
Lead Sponsor
Alliance for Clinical Trials in Oncology
Target Recruit Count
44
Registration Number
NCT00003834
Locations
๐Ÿ‡บ๐Ÿ‡ธ

CCOP - Carle Cancer Center, Urbana, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

CCOP - Duluth, Duluth, Minnesota, United States

๐Ÿ‡บ๐Ÿ‡ธ

CentraCare Clinic, Saint Cloud, Minnesota, United States

and more 18 locations

Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer

Phase 2
Completed
Conditions
First Posted Date
2004-04-12
Last Posted Date
2011-03-28
Lead Sponsor
NYU Langone Health
Registration Number
NCT00004102
Locations
๐Ÿ‡บ๐Ÿ‡ธ

NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York, New York, United States

Oxaliplatin in Treating Patients With Advanced Cancer Plus Liver Dysfunction

First Posted Date
2004-04-12
Last Posted Date
2010-01-06
Lead Sponsor
City of Hope Medical Center
Registration Number
NCT00005077
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States

๐Ÿ‡บ๐Ÿ‡ธ

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

๐Ÿ‡บ๐Ÿ‡ธ

Walter Reed Army Medical Center, Washington, District of Columbia, United States

and more 8 locations

Alvocidib, Oxaliplatin, Fluorouracil, and Leucovorin Calcium in Treating Patients With Advanced Solid Tumors

First Posted Date
2004-04-08
Last Posted Date
2013-12-16
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
46
Registration Number
NCT00080990
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

OSI-7904L and Oxaliplatin in Treating Patients With Refractory or Recurrent Advanced Colorectal Cancer

Phase 1
Completed
Conditions
First Posted Date
2004-04-08
Last Posted Date
2013-06-12
Lead Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Target Recruit Count
15
Registration Number
NCT00081237
Locations
๐Ÿ‡ฌ๐Ÿ‡ง

Christie Hospital N.H.S. Trust, Manchester, England, United Kingdom

๐Ÿ‡ฉ๐Ÿ‡ช

Medizinische Hochschule Hannover, Hannover, Germany

Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer

First Posted Date
2004-04-08
Last Posted Date
2020-02-27
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
146
Registration Number
NCT00081289
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Baptist-South Miami Regional Cancer Program, Miami, Florida, United States

๐Ÿ‡บ๐Ÿ‡ธ

University of California Davis Cancer Center, Sacramento, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey, Illinois, United States

and more 2 locations
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