Nivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation S228P for additional stability and reduced variability. It was developed by Bristol Myers Squibb.
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Nivolumab is indicated to treat unresectable or metastatic melanoma, melanoma as adjuvant treatment, resectable or metastatic non-small cell lung cancer, small cell lung cancer, advanced renal cell carcinoma, classical Hodgkin lymphoma, squamous cell carcinoma of the head and neck, urothelial carcinoma, microsatellite instability-high or mismatch repair defi...
UCSD Moores Cancer Center, La Jolla, California, United States
Emory University, Atlanta, Georgia, United States
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Mount Vernon Hospital, Northwood, United Kingdom
Local Institution, Truro, United Kingdom
Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins, Baltimore, Maryland, United States
Local Institution - 0039, Seattle, Washington, United States
Baptist Health Medical Group Oncology, Miami, Florida, United States
Cancer Center of Kansas - Winfield, Winfield, Kansas, United States
King's Daughter's Medical Center, Ashland, Kentucky, United States
Flaget Memorial Hospital, Bardstown, Kentucky, United States
Local Institution - 0001, Guangzhou, Guangdong, China
Local Institution, Hangzhou, Zhejiang, China
Local Institution - 0055, Milan, Italy
Local Institution - 0039, Graz, Austria
Local Institution - 0075, Bruxelles, Belgium
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Cancer Care Center, Bismarck, North Dakota, United States
Lehigh Valley Hospital, Allentown, Pennsylvania, United States
Texas Oncology Cancer Center - Sugar Land, Sugar Land, Texas, United States
City of Hope National Medical Center, Duarte, California, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Orlando Health, Inc, Orlando, Florida, United States
Georgetown University Med Ctr, Washington, District of Columbia, United States
Universitatsklinikum Jena, Innere Medizin II, Jena, Germany
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