Indomethacin
- Generic Name
- Indomethacin
- Brand Names
- Indocin, Tivorbex
- Drug Type
- Small Molecule
- Chemical Formula
- C19H16ClNO4
- CAS Number
- 53-86-1
- Unique Ingredient Identifier
- XXE1CET956
- Background
Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-ace...
- Indication
Oral indometacin is indicated for symptomatic management of moderate to severe rheumatoid arthritis including acute flares of chronic disease, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.
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- Associated Conditions
- Acute Gouty Arthritis, Joint Pain, Moderate to Severe Osteoarthritis, Moderate to Severe Rheumatoid Arthritis, Moderate to severe ankylosing spondylitis, Myalgia, Patent Ductus Arteriosus (PDA), Acute Shoulder Pain
- Associated Therapies
- -
Single-dose Prophylactic INdomethacin in Extremely Preterm Infants
- Conditions
- Interventions
- First Posted Date
- 2024-08-27
- Last Posted Date
- 2024-08-27
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 500
- Registration Number
- NCT06572917
- Locations
- 🇺🇸
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
🇺🇸Kaiser Roseville, Roseville, California, United States
🇨🇦Foothills Medical Center, Calgary, Alberta, Canada
Brain Blood Flow Responses to Stress: Sex Differences
- Conditions
- Interventions
- First Posted Date
- 2024-02-12
- Last Posted Date
- 2024-04-23
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 26
- Registration Number
- NCT06253702
- Locations
- 🇺🇸
University of Wisconsin, Madison, Wisconsin, United States
A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2023-08-21
- Last Posted Date
- 2023-12-15
- Lead Sponsor
- GlaxoSmithKline
- Registration Number
- NCT05999708
- Locations
- 🇬🇧
GSK Investigational Site, Cambridge, United Kingdom
Clinical Efficacy of Indomethacin in Early Treatment of Acute Pancreatitis
- Conditions
- Interventions
- First Posted Date
- 2022-12-05
- Last Posted Date
- 2023-02-17
- Target Recruit Count
- 188
- Registration Number
- NCT05637281
- Locations
- 🇨🇳
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function
- Conditions
- Interventions
- First Posted Date
- 2022-09-13
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 56
- Registration Number
- NCT05538247
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
A Study Exploring the Use of Challenge Agents in Healthy Volunteers - Intervention Specific Appendix
- Conditions
- Interventions
- First Posted Date
- 2021-03-29
- Last Posted Date
- 2021-06-25
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 10
- Registration Number
- NCT04821323
- Locations
- 🇧🇪
Clinical Pharmacology Unit, Merksem, Belgium
Vaginal Indomethacin for Preterm Labor
- Conditions
- Interventions
- First Posted Date
- 2020-05-27
- Last Posted Date
- 2020-08-11
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 300
- Registration Number
- NCT04404686
Canadian National PDA Treatment Study
- Conditions
- Interventions
- First Posted Date
- 2020-04-15
- Last Posted Date
- 2024-06-21
- Lead Sponsor
- IWK Health Centre
- Target Recruit Count
- 1663
- Registration Number
- NCT04347720
- Locations
- 🇨🇦
Royal Alexandra Hospital, Edmonton, Alberta, Canada
🇨🇦Regina General Hospital, Regina, Saskatchewan, Canada
🇨🇦Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Evaluate the Efficacy and Safety of Oral Hydroxychloroquine, Indomethacin and Zithromax in Subjects With Mild Symptoms of COVID-19
- Conditions
- First Posted Date
- 2020-04-14
- Last Posted Date
- 2020-07-01
- Lead Sponsor
- Perseverance Research Center, LLC
- Target Recruit Count
- 80
- Registration Number
- NCT04344457
- Locations
- 🇺🇸
Covidcraz 19, Llc, New Orleans, Louisiana, United States
🇺🇸Perseverance Research Center, Scottsdale, Arizona, United States
Trial of Indomethacin in Chronic Pancreatitis
- Conditions
- Interventions
- First Posted Date
- 2019-12-20
- Last Posted Date
- 2024-05-06
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 29
- Registration Number
- NCT04207060
- Locations
- 🇺🇸
Ohio State University, Columbus, Ohio, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.