Overview
Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity for various substances. It is used as a gastric decontaminant and emergency medication to treat poisonings following excessive oral ingestion of certain medications or poisons by absorbing most drugs and toxins. However its effects is rendered poor on some compounds including strong acids or bases, methanol and substances with limited absorptive capacity (including iron, lithium, arsenic). It works by binding to the poison in the gastric contents in a reversible fashion thus may be adminstered together with a cathartic to reduce the small intestine transit time. The clinical applications of activated charcoal occured in the early 1800's. While this management for acute poisoning is considered fairly invasive, it is on the World Health Organization's List of Essential Medicines that includes the most important medications needed in a basic health system.
Indication
Used as a antidote to treat poisonings following excessive oral ingestion of certain medications or poisons.
Associated Conditions
- Abdominal Cramping
- Aerophagy
- Bloating
- Constipation
- Delayed Transit Time
- Flatulence
- Belching
- Meteorism
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
---|---|---|---|---|---|
2025/04/02 | Phase 2 | Not yet recruiting | |||
2024/08/30 | Phase 2 | Not yet recruiting | |||
2024/01/23 | Phase 4 | Completed | State University of New York - Upstate Medical University | ||
2023/11/21 | Phase 3 | Recruiting | |||
2023/08/28 | Phase 1 | Recruiting | Javier Villaneuva-Meyer, MD | ||
2022/09/14 | Phase 2 | Not yet recruiting | Waleed Khaild Rahman Kareem Al-kabi | ||
2022/08/23 | Not Applicable | UNKNOWN | |||
2022/07/22 | Phase 4 | Not yet recruiting | |||
2022/02/08 | Phase 2 | Active, not recruiting | |||
2021/06/16 | Phase 2 | Withdrawn |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
---|---|---|---|---|---|
Peaceful Mountain, Inc. | 43846-0039 | TOPICAL | 12 [hp_X] in 1 g | 5/21/2025 | |
VistaPharm, LLC | 66689-201 | ORAL | 50 g in 240 mL | 11/20/2023 | |
Bestmade Natural Products | 82969-5119 | ORAL | 3 [hp_X] in 62.5 mg | 6/5/2025 | |
VistaPharm, LLC | 66689-202 | ORAL | 50 g in 240 mL | 11/20/2023 | |
HF Acquisition Co LLC, DBA HealthFirst | 51662-1200 | ORAL | 208 mg in 1 mL | 2/19/2020 | |
Deseret Biologicals, Inc. | 43742-2178 | ORAL | 12 [hp_X] in 1 mL | 4/22/2025 | |
VistaPharm, LLC | 66689-203 | ORAL | 50 g in 240 mL | 11/20/2023 | |
King Bio Inc. | 57955-2828 | ORAL | 10 [hp_X] in 59 mL | 5/20/2025 | |
Aspen Veterinary Resources, Ltd. | 46066-313 | ORAL | 55 [arb'U] in 1 mL | 6/6/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
---|---|---|---|
No EMA approvals found for this drug. |
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
NORIT TABLET 125 mg | SIN06063P | TABLET | 125 mg | 6/3/1991 | |
NORIT CAPSULE 200 mg | SIN05799P | CAPSULE | 200 mg | 5/7/1991 | |
ULTRACARBON TABLET 250 mg | SIN05853P | TABLET | 250 mg | 5/20/1991 | |
CHARCOAL TABLET 200 mg | SIN10625P | TABLET | 200 mg | 1/7/1999 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
---|---|---|---|---|---|
Medicinal Charcoal Granules | 国药准字HJ20220076 | 化学药品 | 颗粒剂 | 2/20/2023 | |
Medicinal Charcoal Tablets | 国药准字H33020476 | 化学药品 | 片剂 | 4/28/2020 | |
Medicinal Charcoal Tablets | 国药准字H11021126 | 化学药品 | 片剂 | 11/27/2020 | |
Medicinal Charcoal Tablets | 国药准字H31021642 | 化学药品 | 片剂 | 2/10/2020 | |
Medicinal Charcoal Tablets | 国药准字H13022797 | 化学药品 | 片剂 | 9/28/2020 | |
Medicinal Charcoal Tablets | 国药准字H33020477 | 化学药品 | 片剂 | 4/28/2020 | |
Medicinal Charcoal Capsules | 国药准字H10960103 | 化学药品 | 胶囊剂 | 9/28/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
---|---|---|---|---|---|
No PPB approvals found for this drug. |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
---|---|---|---|---|---|
NutriVital Activated Charcoal Plus | 323692 | Medicine | A | 9/17/2019 | |
CHARCOCAPS | 93912 | Medicine | A | 4/8/2003 | |
Biochemics Acid and Indigestion | 120020 | Medicine | A | 6/22/2005 | |
CARBOSORB XS activated charcoal 50 g/250 mL and sorbitol 70.75 g/250 mL suspension bottle | 307429 | Medicine | A | 7/25/2018 | |
CHARCOTRACE activated charcoal 120 mg/3 mL injection vial | 100313 | Medicine | A | 7/20/2005 | |
BLOAT | 376730 | Medicine | A | 10/22/2021 | |
red seal Activated Charcoal 300 mg | 441210 | Medicine | A | 2/15/2024 | |
Activated Charcoal | 242093 | Medicine | A | 6/12/2015 | |
CARBOSORB X activated charcoal 50 g/250 mL suspension bottle | 106470 | Medicine | A | 7/23/2004 | |
Faulding Gut Calm | 401186 | Medicine | A | 12/16/2022 |
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