Clodronic acid
- Generic Name
- Clodronic acid
- Brand Names
- Clasteon
- Drug Type
- Small Molecule
- Chemical Formula
- CH4Cl2O6P2
- CAS Number
- 10596-23-3
- Unique Ingredient Identifier
- 0813BZ6866
- Background
Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic aci...
- Indication
Clodronic acid is indicated as an adjunct in the management of osteolysis from bone metastases of malignant tumors and for management of hypercalcemia of malignancy.
- Associated Conditions
- Hypercalcemia of Malignancy, Osteolytic Bone metastases
- Associated Therapies
- -
Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients
- First Posted Date
- 2024-02-16
- Last Posted Date
- 2024-02-16
- Lead Sponsor
- SPA Società Prodotti Antibiotici S.p.A.
- Target Recruit Count
- 296
- Registration Number
- NCT06263517
- Locations
- 🇮🇹
Ospedale San Pellegrino, Castiglione delle Stiviere, Mantova, Italy
🇮🇹Ospedale San Pietro, Rome, Italy
🇮🇹Centro Riabilitativo Polifunzionale Teresio Borsalino, Alessandria, Italy
Combined Drug Therapy in Lateral Fragility Fractures of the Femur
- First Posted Date
- 2022-01-10
- Last Posted Date
- 2022-02-04
- Target Recruit Count
- 50
- Registration Number
- NCT05183308
- Locations
- 🇮🇹
AOUC Policlinico di Bari - UOC Ortopedia e Traumatologia, Bari, Italy
Locally Administered Clodronate in the Prevention of Aseptic Implant Loosening
- First Posted Date
- 2019-01-15
- Last Posted Date
- 2019-01-18
- Lead Sponsor
- University of Oulu
- Target Recruit Count
- 19
- Registration Number
- NCT03803839
Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy
- First Posted Date
- 2011-02-08
- Last Posted Date
- 2017-12-08
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 59
- Registration Number
- NCT01291433
- Locations
- 🇫🇷
Hôpital Saint-Louis, Paris, France
🇫🇷Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Bisphosphonates and Impaction Grafting in Hip Revision
- Conditions
- Interventions
- First Posted Date
- 2008-04-14
- Last Posted Date
- 2017-08-15
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 32
- Registration Number
- NCT00658268
- Locations
- 🇸🇪
Lund University Hospital, Lund, Sweden
Clodronate With or Without Chemotherapy and/or Hormonal Therapy in Treating Women With Stage I or Stage II Breast Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2017-12-13
- Lead Sponsor
- NSABP Foundation Inc
- Target Recruit Count
- 3323
- Registration Number
- NCT00009945
- Locations
- 🇺🇸
Altru Cancer Center, Grand Forks, North Dakota, United States
🇺🇸Fletcher Allen Health Care - University Health Center Campus, Burlington, Vermont, United States
🇺🇸CCOP - Mayo Clinic Scottsdale Oncology Program, Scottsdale, Arizona, United States
Drug Development Updates
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