Clodronic acid
- Generic Name
- Clodronic acid
- Brand Names
- Clasteon
- Drug Type
- Small Molecule
- Chemical Formula
- CH4Cl2O6P2
- CAS Number
- 10596-23-3
- Unique Ingredient Identifier
- 0813BZ6866
Overview
Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid. Clodronic acid is not FDA approved, but is approved in Canada.
Background
Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid. Clodronic acid is not FDA approved, but is approved in Canada.
Indication
Clodronic acid is indicated as an adjunct in the management of osteolysis from bone metastases of malignant tumors and for management of hypercalcemia of malignancy.
Associated Conditions
- Hypercalcemia of Malignancy
- Osteolytic Bone metastases
Clinical Trials
FDA Approved Products
Singapore Approved Products
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