MedPath

Epoprostenol

Generic Name
Epoprostenol
Brand Names
Flolan, Veletri
Drug Type
Small Molecule
Chemical Formula
C20H32O5
CAS Number
35121-78-9
Unique Ingredient Identifier
DCR9Z582X0

Overview

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.

Background

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.

Indication

For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.

Associated Conditions

  • Pulmonary Arterial Hypertension (PAH)

FDA Approved Products

Veletri
Manufacturer:Actelion Pharmaceuticals US, Inc.
Route:INTRAVENOUS
Strength:1.5 mg in 10 mL
Approved: 2022/07/31
NDC:66215-402
epoprostenol
Manufacturer:Sun Pharmaceutical Industries, Inc.
Route:INTRAVENOUS
Strength:0.5 mg in 10 mL
Approved: 2021/01/16
NDC:62756-059
FLOLAN
Manufacturer:GlaxoSmithKline LLC
Route:INTRAVENOUS
Strength:1.5 mg in 1 1
Approved: 2021/08/24
NDC:0173-0519
Veletri
Manufacturer:Actelion Pharmaceuticals US, Inc.
Route:INTRAVENOUS
Strength:0.5 mg in 10 mL
Approved: 2022/07/31
NDC:66215-403
epoprostenol
Manufacturer:Sun Pharmaceutical Industries, Inc.
Route:INTRAVENOUS
Strength:1.5 mg in 10 mL
Approved: 2021/01/16
NDC:62756-060

Singapore Approved Products

VELETRI POWDER FOR SOLUTION FOR INFUSION 1.5MG/VIAL
Manufacturer:Patheon Italia S.p.A
Form:INJECTION, POWDER, FOR SOLUTION
Strength:1.5mg
Online:Yes
Approved: 2018/01/11
Approval:SIN15406P
FLOLAN FOR INFUSION 0.5 mg/vial
Manufacturer:GLAXOSMITHKLINE MANUFACTURING S.P.A. (Powder), GLAXO OPERATIONS UK LTD.(TRADING AS GLAXO WELLCOME OPERATIONS)(Diluent-Manufacture,Primary Packager)
Form:INJECTION, POWDER, FOR SOLUTION
Strength:0.5 mg/vial
Online:Yes
Approved: 1988/07/04
Approval:SIN02241P
VELETRI POWDER FOR SOLUTION FOR INFUSION 0.5MG/VIAL
Manufacturer:Patheon Italia S.p.A
Form:INJECTION, POWDER, FOR SOLUTION
Strength:0.5mg
Online:Yes
Approved: 2018/01/11
Approval:SIN15405P

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