Propranolol

Generic Name: Propranolol

Brand Names: Hemangeol, Hemangiol, Inderal, Innopran

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₁NO_₂

CAS Number: 525-66-6

Unique Ingredient Identifier: 9Y8NXQ24VQ

Background: Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication: Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions: Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)

Associated Therapies: -

Clinical Trials

Propranolol for Challenging Behaviors in Autism

Phase 2

Active, not recruiting

Conditions: Autism Spectrum Disorder
Developmental Disability
Aggression
Self-Injurious Behavior
Challenging Behavior

Interventions: Drug: Propranolol

First Posted Date: 2019-08-06

Last Posted Date: 2024-02-07

Lead Sponsor: Rutgers, The State University of New Jersey

Target Recruit Count: 6

Registration Number: NCT04047355

Locations: 🇺🇸
Department of Pediatrics, Division of Pediatric Neurology, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States

Clinical Study of Propranolol Combined With Neoadjuvant Chemotherapy in Gastric Cancer

Phase 2

Conditions: Gastric Cancer

Interventions: Drug: Propranolol

First Posted Date: 2019-07-02

Last Posted Date: 2019-11-26

Lead Sponsor: Yijing He

Target Recruit Count: 78

Registration Number: NCT04005365

Locations: 🇨🇳
Xiangya Hospital Central South University, Changsha, Hunan, China

Brief Stresses Experimental Study

Phase 1

Terminated

Conditions: DNA Damage
Psychological Stress

Interventions: Drug: Placebo oral capsule
Drug: Propranolol
Behavioral: Acute stress task
Behavioral: No stress task

First Posted Date: 2019-03-28

Last Posted Date: 2023-07-18

Lead Sponsor: Dana Bovbjerg

Target Recruit Count: 239

Registration Number: NCT03893617

Locations: 🇺🇸
UPMC Shadyside, Pittsburgh, Pennsylvania, United States

HVPG-guided Laparoscopic Versus Endoscopic Therapy for Variceal Rebleeding in Portal Hypertension: A Multicenter Randomized Controlled Trial (CHESS1803)

Not Applicable

Conditions: Portal Hypertension
Variceal Rebleeding

Interventions: Drug: Propranolol
Procedure: Laparoscopic splenectomy and pericardial devascularization
Procedure: Endoscopic therapy

First Posted Date: 2018-12-20

Last Posted Date: 2021-08-17

Lead Sponsor: Nanfang Hospital, Southern Medical University

Target Recruit Count: 40

Registration Number: NCT03783065

Locations: 🇨🇳
Xingtai People's Hospital, Xingtai, Hebei, China
🇨🇳
The First Hospital of Lanzhou University, Lanzhou, Gansu, China
🇨🇳
The Fifth Medical Center of Chinese PLA General Hospital, Beijing, Beijing, China

and more 1 locations

Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension

Phase 2

Conditions: Cirrhosis
Portal Hypertension
Variceal Hemorrhage

Interventions: Drug: Propranolol
Drug: Carvedilol
Drug: Rosuvastatin
Drug: Placebo

First Posted Date: 2018-10-25

Last Posted Date: 2019-05-14

Lead Sponsor: Universidade Federal do Rio de Janeiro

Target Recruit Count: 80

Registration Number: NCT03720067

Locations: 🇧🇷
Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

Phase 2

Recruiting

Conditions: Alcohol Drinking

Interventions: Drug: Propranolol
Drug: Placebo

First Posted Date: 2018-07-17

Last Posted Date: 2024-08-13

Lead Sponsor: Yale University

Target Recruit Count: 20

Registration Number: NCT03588754

Locations: 🇺🇸
Yale University School of Medicine, New Haven, Connecticut, United States

Treat_CCM: Propranolol in Familial Cerebral Cavernous Malformation

Phase 2

Completed

Conditions: Cerebral Cavernous Malformation

Interventions: Drug: Propranolol

First Posted Date: 2018-07-17

Last Posted Date: 2022-02-25

Lead Sponsor: Mario Negri Institute for Pharmacological Research

Target Recruit Count: 71

Registration Number: NCT03589014

Locations: 🇮🇹
IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
🇮🇹
Fondazione Policlinico Universitario "A. Gemelli", Roma, RM, Italy
🇮🇹
ASST Grande Ospedale Metropolitano Niguarda, Milano, MI, Italy

and more 3 locations