Tipifarnib (R-115777) is a substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors. It is also called Zarnestra. In June 2005, the FDA issued a Not Approvable Letter for Zarnestra.
Investigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors.
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario, Canada
London Regional Cancer Program at London Health Sciences Centre, London, Ontario, Canada
City of Hope, Duarte, California, United States
M D Anderson Cancer Center, Houston, Texas, United States
M D Anderson Cancer Center, Houston, Texas, United States
Mason District Hospital, Havana, Illinois, United States
Pennsylvania Hospital, Philadelphia, Pennsylvania, United States
Graham Hospital Association, Canton, Illinois, United States
Southwest Oncology Group, San Antonio, Texas, United States
University of Iowa College of Medicine, Iowa City, Iowa, United States
University of Rochester Cancer Center, Rochester, New York, United States
Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States
Kaplan Cancer Center, New York, New York, United States
Mayo Clinic, Rochester, Minnesota, United States
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, United States
Mayo Clinic, Rochester, Minnesota, United States
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