Interferon alfa-2b (Intron A)

概览

Interferon alfa-2b is a form of recombinant human interferon used to treat hepatitis B and C infection, genital warts, hairy cell leukemia, follicular lymphoma, malignant melanoma, and AIDs-related Kaposi's sarcoma.

作用机制

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which upon dimerization activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.

适应症

For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma.

• Chronic Hepatitis B Infection
• Chronic Hepatitis C Virus (HCV) Infection
• Condylomata Acuminata (External)
• Follicular Non-Hodgkin's Lymphoma
• Hairy Cell Leukemia (HCL)
• Kaposi's Sarcoma
• Malignant Melanoma