Hydroxyzine

Generic Name
Hydroxyzine
Brand Names
Atarax, Vistaril
Drug Type
Small Molecule
Chemical Formula
C21H27ClN2O2
CAS Number
68-88-2
Unique Ingredient Identifier
30S50YM8OG
Background

Hydroxyzine is a first-generation histamine H-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties. It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus. Th...

Indication

Hydroxyzine is indicated for the symptomatic relief of anxiety and tension associated with psychoneuroses, and as an adjunct in organic disease states in which anxiety is manifested. It is also indicated in the treatment of histamine-mediated pruritus and pruritus due to allergic conditions such as chronic urticaria.
...

Associated Conditions
Anxiety, Nausea and vomiting, Pruritus
Associated Therapies
-
Clinical Trials
Related News

Efficacy of Hydroxyzine for Patients With Panic Disorder

Phase 4
Not yet recruiting
Conditions
Panic Disorder
Interventions
Drug: Hydroxyzine
Drug: Escitalopram Oxalate
First Posted Date
2023-02-21
Last Posted Date
2023-02-21
Lead Sponsor
Sultan Qaboos University
Target Recruit Count
80
Registration Number
NCT05737511

Sedation and Nursing Management in EEG Recording in Children

First Posted Date
2022-08-09
Last Posted Date
2022-08-09
Lead Sponsor
Suleyman Demirel University
Target Recruit Count
180
Registration Number
NCT05492812
Locations
🇹🇷

Suleyman Demirel University, Isparta, Turkey

Melatonin Versus Hydroxizin for Pre Operative Anxiety in Elderly Patients With Hip Fracture

First Posted Date
2022-02-04
Last Posted Date
2022-02-04
Lead Sponsor
Mongi Slim Hospital
Target Recruit Count
50
Registration Number
NCT05224167

Preoperative Use of Alprazolam and Hydroxyzine in Anxiety

First Posted Date
2019-12-03
Last Posted Date
2019-12-06
Lead Sponsor
Istanbul Medeniyet University
Target Recruit Count
90
Registration Number
NCT04184141

Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years

First Posted Date
2019-08-28
Last Posted Date
2024-01-24
Lead Sponsor
University of Washington
Target Recruit Count
37
Registration Number
NCT04068948
Locations
🇺🇸

University of Washington Center for Pediatric Dentistry, Seattle, Washington, United States

Presurgery Anxiolysis in Children Treated With Hydroxyzine Versus Non-pharmacological Intervention (Distractoria Technique Clown)

Phase 4
Terminated
Conditions
Anxiety
Interventions
Drug: Hydroxyzine
Other: Clowns intervention
First Posted Date
2017-10-30
Last Posted Date
2020-08-11
Lead Sponsor
Hospital San Carlos, Madrid
Target Recruit Count
170
Registration Number
NCT03324828
Locations
🇪🇸

Hospital Clinico San Carlos, Madrid, Spain

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Comparing the Efficacy of Pregabalin and Hydroxyzine on the Anxiety Score

First Posted Date
2012-08-30
Last Posted Date
2016-10-11
Lead Sponsor
Poitiers University Hospital
Target Recruit Count
306
Registration Number
NCT01675986
Locations
🇫🇷

CHU de POITIERS, Poitiers, France

Interaction Between Drug and Placebo Effect:Randomized Placebo Controlled Trials May Not be Accurate in Determining Drug Effect Size

First Posted Date
2011-12-29
Last Posted Date
2017-03-03
Lead Sponsor
King Faisal Specialist Hospital & Research Center
Target Recruit Count
480
Registration Number
NCT01501591
Locations
🇸🇦

King Faisal Specialist Hospital & research Center, Riyadh, Saudi Arabia

Effects of Levocetirizine and Hydroxyzine on Cognitive and Psychomotor Functioning During Simulated Diving

First Posted Date
2011-12-21
Last Posted Date
2013-11-06
Lead Sponsor
Utrecht Institute for Pharmaceutical Sciences
Target Recruit Count
24
Registration Number
NCT01496911
Locations
🇳🇱

Royal Netherlands Navy, Den Helder, Noord Holland, Netherlands

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