Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
A Study of the Efficacy and Safety of Topiramate in Obese, Type 2 Diabetic Patients Inadequately Controlled on Sulfonylurea Therapy
- Conditions
- First Posted Date
- 2005-10-04
- Last Posted Date
- 2011-06-08
- Target Recruit Count
- 31
- Registration Number
- NCT00231634
A Study of Safety and Efficacy of Topiramate in Male Patients With Abdominal Obesity
- Conditions
- First Posted Date
- 2005-10-04
- Last Posted Date
- 2011-06-08
- Target Recruit Count
- 68
- Registration Number
- NCT00231608
A Study on Efficacy and Safety of Topiramate in Treatment of Obese Subjects With Dyslipidemia
- Conditions
- First Posted Date
- 2005-10-04
- Last Posted Date
- 2011-06-08
- Target Recruit Count
- 179
- Registration Number
- NCT00231621
A Study on Efficacy and Safety of Topiramate OROS Controlled-Release in Obese, Type 2 Diabetic Subjects Managed With Diet or Metformin
- Conditions
- First Posted Date
- 2005-10-04
- Last Posted Date
- 2011-06-08
- Target Recruit Count
- 113
- Registration Number
- NCT00231647
A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine
- Conditions
- First Posted Date
- 2005-10-04
- Last Posted Date
- 2010-11-19
- Target Recruit Count
- 768
- Registration Number
- NCT00231595
A Study on Safety and Efficacy of Two Doses of Topiramate as Monotherapy in the Treatment of Newly Diagnosed or Recurrent Epilepsy
- Conditions
- First Posted Date
- 2005-10-04
- Last Posted Date
- 2011-06-08
- Target Recruit Count
- 750
- Registration Number
- NCT00231556
A Study of the Effectiveness and Safety of Topiramate Monotherapy in Patients With Recently Diagnosed Partial-Onset Seizure
- Conditions
- First Posted Date
- 2005-10-03
- Last Posted Date
- 2010-11-15
- Target Recruit Count
- 451
- Registration Number
- NCT00230698
Topiramate to Reduce Cocaine Dependence
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2012-04-19
- Lead Sponsor
- Bankole Johnson
- Target Recruit Count
- 25
- Registration Number
- NCT00223626
- Locations
- 🇺🇸
University of Virginia CARE Center for Addiction Research & Education, Charlottesville, Virginia, United States
🇺🇸UVA CARE Richmond, Richmond, Virginia, United States
Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2012-04-13
- Lead Sponsor
- Lindner Center of HOPE
- Target Recruit Count
- 87
- Registration Number
- NCT00280839
- Locations
- 🇺🇸
University of Cincinnati Medical Center, Cincinnati, Ohio, United States
New Medications to Treat Alcohol Dependence
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2012-02-07
- Lead Sponsor
- Bankole Johnson
- Target Recruit Count
- 29
- Registration Number
- NCT00223639
- Locations
- 🇺🇸
UVA CARE Richmond, Richmond, Virginia, United States
🇺🇸UVA CARE, Charlottesville, Virginia, United States
Drug Development Updates
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