Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2011-06-10
- Target Recruit Count
- 328
- Registration Number
- NCT00210912
A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2014-06-16
- Lead Sponsor
- Emory University
- Registration Number
- NCT00208858
- Locations
- 🇺🇸
Atlanta VA Medical Center, Decatur, Georgia, United States
Topiramate in the Treatment of Posttraumatic Stress Disorder in Civilians
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2009-04-29
- Lead Sponsor
- Creighton University
- Target Recruit Count
- 60
- Registration Number
- NCT00208130
- Locations
- 🇺🇸
Creighton University Psychiatry and Research Center, Omaha, Nebraska, United States
Topiramate Augmentation in the Treatment of Obsessive-Compulsive Disorder
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2018-05-30
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 24
- Registration Number
- NCT00211744
- Locations
- 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States
Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD)
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2009-07-29
- Target Recruit Count
- 40
- Registration Number
- NCT00203463
- Locations
- 🇺🇸
Tuscaloosa Research & Education Advancement Corporation, Tuscaloosa, Alabama, United States
A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2009-01-23
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 60
- Registration Number
- NCT00203190
- Locations
- 🇺🇸
Jefferson Headache Center, Philadelphia, Pennsylvania, United States
Safety & Efficacy Study Using Topiramate in Posttraumatic Stress Disorder
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2007-05-30
- Lead Sponsor
- University of Oklahoma
- Target Recruit Count
- 50
- Registration Number
- NCT00204386
- Locations
- 🇺🇸
The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2005-12-16
- Lead Sponsor
- Neurocare
- Target Recruit Count
- 44
- Registration Number
- NCT00200941
- Locations
- 🇺🇸
Neurocare, Newton, Massachusetts, United States
Study to Determine the Efficacy and Safety of Adjunctive Topiramate in the Treatment of Obsessive-Compulsive Disorder
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2011-10-05
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 96
- Registration Number
- NCT00187928
- Locations
- 🇺🇸
UF Health Science Center, Gainesville, Florida, United States
Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP)
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2020-09-02
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 12
- Registration Number
- NCT00182455
- Locations
- 🇨🇦
MacAnxiety Research Centre, Hamilton, Ontario, Canada
Drug Development Updates
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