Topiramate

Generic Name
Topiramate
Brand Names
Eprontia, Qsymia, Qudexy, Topamax, Trokendi
Drug Type
Small Molecule
Chemical Formula
C12H21NO8S
CAS Number
97240-79-4
Unique Ingredient Identifier
0H73WJJ391
Background

Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
...

Indication

Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...

Associated Conditions
Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
Associated Therapies
Chronic Weight Management therapy, Weight Reduction
Clinical Trials
Related News

Topiramate for Alcohol Use in Posttraumatic Stress Disorder

First Posted Date
2011-08-03
Last Posted Date
2022-03-03
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
4
Registration Number
NCT01408641
Locations
🇺🇸

Baltimore VA, VA Maryland Health Care System, Baltimore, Maryland, United States

Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity

First Posted Date
2011-05-11
Last Posted Date
2021-06-09
Lead Sponsor
University of Iowa
Target Recruit Count
136
Registration Number
NCT01351753
Locations
🇺🇸

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Levetiracetam Versus Topiramate as Adjunctive Therapy to Evaluate Efficacy and Safety in Subjects With Refractory Partial Onset Seizures

Phase 4
Completed
Conditions
Epilepsy
Interventions
Drug: Levetiracetam
Drug: Topiramate
First Posted Date
2010-10-28
Last Posted Date
2017-08-15
Lead Sponsor
UCB Korea Co., Ltd.
Target Recruit Count
343
Registration Number
NCT01229735
Locations
🇰🇷

18, Seoul, Korea, Republic of

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13, Daegu, Korea, Republic of

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23, Kyunggi-Do, Korea, Republic of

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Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?

Not Applicable
Completed
Conditions
Migraine
Interventions
Drug: Amitriptyline
Drug: Topiramate
First Posted Date
2010-07-13
Last Posted Date
2017-10-11
Lead Sponsor
Rambam Health Care Campus
Target Recruit Count
67
Registration Number
NCT01161017
Locations
🇮🇱

Rambam Medical Center, Haifa, Israel

Efficacy of Topiramate for Hospitalized Patients With Alcoholism

Phase 2
Completed
Conditions
Alcohol Dependence
Interventions
Drug: Topiramate
First Posted Date
2010-06-17
Last Posted Date
2011-06-23
Lead Sponsor
Chiang Mai University
Target Recruit Count
90
Registration Number
NCT01145677
Locations
🇹🇭

Suanprung Psychiatric Hospital, Muang, ChiangMai, Thailand

🇹🇭

Chiang Mai Drug Dependence Treatment Center, Maerim, Chiang Mai, Thailand

🇹🇭

Maharaj Nakorn Chiang Mai Hospital, Muang, ChiangMai, Thailand

Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study

Phase 4
Conditions
Alcohol Dependence
Interventions
Drug: Topiramate
First Posted Date
2010-06-03
Last Posted Date
2011-08-15
Lead Sponsor
Chiang Mai University
Target Recruit Count
150
Registration Number
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Locations
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Maharaj Nakorn Chiang Mai Hospital, Muang, Chiang Mai, Thailand

Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents

First Posted Date
2010-04-26
Last Posted Date
2020-09-16
Lead Sponsor
Brown University
Target Recruit Count
66
Registration Number
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Locations
🇺🇸

Brown University, Center for Alcohol and Addiction Studies, Providence, Rhode Island, United States

Acupuncture in Chronic Migraine: A Randomized Controlled Trial

Not Applicable
Completed
Conditions
Patients With Chronic Migraine
Interventions
Procedure: acupuncture
Drug: topiramate
First Posted Date
2010-03-31
Last Posted Date
2013-08-14
Lead Sponsor
Kuang Tien General Hospital
Target Recruit Count
68
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Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy

First Posted Date
2010-03-16
Last Posted Date
2014-06-03
Lead Sponsor
University of California, San Francisco
Target Recruit Count
30
Registration Number
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Locations
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San Francisco VA Medical Center, San Francisco, California, United States

A Dose-Finding Study of Topiramate (JNS019) in Participants With Migraine

Phase 2
Completed
Conditions
Migraine
Interventions
Drug: Topiramate
Drug: Placebo
First Posted Date
2010-03-05
Last Posted Date
2013-07-02
Lead Sponsor
Janssen Pharmaceutical K.K.
Target Recruit Count
387
Registration Number
NCT01081795
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