Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
Medical Therapies for Chronic Post-Traumatic Headaches
- Conditions
- Interventions
- First Posted Date
- 2009-03-16
- Last Posted Date
- 2013-04-23
- Lead Sponsor
- Madigan Army Medical Center
- Target Recruit Count
- 64
- Registration Number
- NCT00862095
- Locations
- 🇺🇸
Madigan Army Medical Center, Tacoma, Washington, United States
Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine
- First Posted Date
- 2009-02-18
- Last Posted Date
- 2012-01-13
- Lead Sponsor
- Clinvest
- Target Recruit Count
- 55
- Registration Number
- NCT00846495
- Locations
- 🇺🇸
Physician Associates LLC, Oviedo, Florida, United States
🇺🇸Clinvest, Springfield, Missouri, United States
Topiramate to Aid Smoking Cessation in Alcohol Dependent Men
- Conditions
- Interventions
- First Posted Date
- 2008-12-04
- Last Posted Date
- 2017-01-31
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 132
- Registration Number
- NCT00802412
- Locations
- 🇺🇸
VA San Diego Healthcare System, San Diego, CA, San Diego, California, United States
Quantification of the Antidyskinetic Effect of Amantadine and Topiramate in Parkinson's Disease
- Conditions
- Interventions
- First Posted Date
- 2008-11-20
- Last Posted Date
- 2018-02-01
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 3
- Registration Number
- NCT00794313
- Locations
- 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States
Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine
- Conditions
- Interventions
- First Posted Date
- 2008-10-22
- Last Posted Date
- 2020-12-17
- Lead Sponsor
- University of South Alabama
- Registration Number
- NCT00777218
- Locations
- 🇺🇸
University of South Alabama Department of Neurology, Mobile, Alabama, United States
NINDS CRC Chronic Migraine Treatment Trial
- Conditions
- Interventions
- First Posted Date
- 2008-10-15
- Last Posted Date
- 2012-01-24
- Lead Sponsor
- Anne Lindblad
- Target Recruit Count
- 191
- Registration Number
- NCT00772031
- Locations
- 🇺🇸
Abington Neurological Associates, Ltd., 1245 Highland Avenue, Ste 301, Abington, Pennsylvania, United States
🇺🇸ClinExcel Research 7908 Cincinnati-Dayton Rd, Ste J, West Chester, Ohio, United States
🇺🇸Guilford Neurologic Associates, 1126 North Church Street, Suite 200, Greensboro, North Carolina, United States
Topiramate for Binge Eating Disorder Among Adolescents
- Conditions
- First Posted Date
- 2008-10-08
- Last Posted Date
- 2008-10-08
- Lead Sponsor
- The Zucker Hillside Hospital
- Registration Number
- NCT00768677
- Locations
- 🇺🇸
The Zucker Hillside Hospital, Glen Oaks, New York, United States
Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2008-09-19
- Last Posted Date
- 2017-08-16
- Lead Sponsor
- UConn Health
- Target Recruit Count
- 57
- Registration Number
- NCT00755716
- Locations
- 🇺🇸
University of Connecticut Halth Center, Farmington, Connecticut, United States
Is Topiramate Effective in Treating Dizziness in Patient's With Migraine-Associated Dizziness
- Conditions
- Interventions
- First Posted Date
- 2008-08-11
- Last Posted Date
- 2015-03-06
- Lead Sponsor
- University of California, San Francisco
- Registration Number
- NCT00732108
- Locations
- 🇺🇸
University of California, San Francisco, San Francisco, California, United States
Placebo Controled Clinical Trial Using Topiramate To Treat Posttraumatic Stress Disorder (PTSD) Patients.
- Conditions
- Interventions
- First Posted Date
- 2008-07-31
- Last Posted Date
- 2014-08-26
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 35
- Registration Number
- NCT00725920
- Locations
- 🇧🇷
Federal University of Sao Paulo, Sao Paulo, Brazil
Drug Development Updates
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