DeepMed Research

Choriogonadotropin alfa

Generic Name: Choriogonadotropin alfa

Brand Names: Ovidrel, Ovitrelle, Pregnyl

Drug Type: Biotech

CAS Number: 177073-44-8

Unique Ingredient Identifier: 6413W06WR3

Background: Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH.

Indication: For the treatment of female infertility

Associated Conditions: Secondary Hypogonadotrophic hypogonadism

Associated Therapies: Assisted Reproductive Technology therapy, Ovulation induction therapy

Clinical Trials

Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer(FET)

Phase 4

Recruiting

Conditions: Infertilities
Embryo Transfer

Interventions: Drug: Estradiol + Progesterone
Drug: Ovitrelle ( Hcg 250 mcg)

First Posted Date: 2025-03-26

Last Posted Date: 2025-04-02

Lead Sponsor: Fundacion Clinic per a la Recerca Biomédica

Target Recruit Count: 334

Registration Number: NCT06896617

Locations: 🇪🇸
Laura Burunat, Barcelona, Spain

Clinical Research Study to Learn About the Effect and Safety of Different Doses of FE 999302 When Given as a Single Dose for Final Development of the Eggs After Ovarian Stimulation

Phase 2

Withdrawn

Conditions: Infertility

Interventions: Drug: Ovitrelle
Drug: FE 999302
Drug: Novarel

First Posted Date: 2022-10-07

Last Posted Date: 2023-01-09

Lead Sponsor: Ferring Pharmaceuticals

Registration Number: NCT05571111

Locations: 🇪🇸
Ferring Investigational Site, Valencia, Spain

Can Biotin Supplementation be Used to Mask hCG Abuse?

Early Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Choriogonadotropin Alpha
Dietary Supplement: biotin
Other: Microcellulose filler

First Posted Date: 2022-07-11

Last Posted Date: 2023-02-03

Lead Sponsor: Sports Medicine Research and Testing Laboratory

Target Recruit Count: 10

Registration Number: NCT05450900

Locations: 🇺🇸
Sports Medicine Research and Testing Laboratory, Salt Lake City, Utah, United States

Comparison of Triggers in Double Ovarian Stimulation (DuoStim).

Phase 4

Conditions: IVF
LOW OVARIAN RESPONSE

Interventions: Drug: Ovitrelle® (hCG)
Drug: Decapeptyl 0.1 mg® (a-GnRH) and Ovitrelle® (hCG) used together
Drug: Triptorelin acetate (a-GnRH)

First Posted Date: 2022-04-11

Last Posted Date: 2022-04-11

Lead Sponsor: Instituto Bernabeu

Target Recruit Count: 165

Registration Number: NCT05321511

Locations: 🇪🇸
Instituto Bernabeu, Madrid, Spain

A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve

Not Applicable

Conditions: Poor Ovarian Response

Interventions: Drug: Ovidrel
Drug: Troprilin

First Posted Date: 2021-01-22

Last Posted Date: 2021-01-28

Lead Sponsor: Nanjing University

Target Recruit Count: 310

Registration Number: NCT04717752

Locations: 🇨🇳
Reproductive Medicine Center, The affiliated Drum Towel Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China

hCG Priming in Women With Low Ovarian Reserve

Phase 4

Completed

Conditions: Infertility, Female
Ovarian Reserve
In Vitro Fertilization

Interventions: Drug: Ovitrelle

First Posted Date: 2020-11-25

Last Posted Date: 2022-08-25

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 20

Registration Number: NCT04643925

Locations: 🇩🇰
Rigshospitalet, København Ø, Denmark

Follicle Size and Oocyte Development

Not Applicable

Completed

Conditions: IVF Treatment

Interventions: Diagnostic Test: Follicle measurment
Drug: Ovitrelle ( Hcg 250 mcg)
Drug: Decapeptyl ( GnRH Agonist 0.1 mg*2 )

First Posted Date: 2018-09-07

Last Posted Date: 2022-06-24

Lead Sponsor: Sheba Medical Center

Target Recruit Count: 200

Registration Number: NCT03660813

Locations: 🇮🇱
Sheba Medical Center, Ramat Gan, Israel

Endometrial Preparation in Frozen Embryo Transfer Cycles

Not Applicable

Conditions: Reproductive Behavior

Interventions: Procedure: endometrial preparation for frozen blastocyst transfer
Drug: Estrofem
Drug: Letrozole
Drug: Endometrin 100Mg Vaginal Insert
Drug: Ovidrel

First Posted Date: 2018-05-30

Last Posted Date: 2018-05-30

Lead Sponsor: Meir Medical Center

Target Recruit Count: 100

Registration Number: NCT03540979

Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers

Phase 4

Completed

Conditions: hCG
BRCA1 Mutation
BRCA2 Mutation

Interventions: Drug: Ovitrelle

First Posted Date: 2018-04-12

Last Posted Date: 2023-09-07

Lead Sponsor: University Hospital, Ghent

Target Recruit Count: 33

Registration Number: NCT03495609

Locations: 🇧🇪
Ghent University Hospital, Ghent, East-Flanders, Belgium

Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole

Phase 2

Completed

Conditions: Polycystic Ovary Syndrome

Interventions: Drug: Progesterone Vaginal Gel 8%
Drug: Letrozole Oral Tablet
Diagnostic Test: pelvic ultrasound
Drug: Ovidrel 250 MCG Per 0.5 ML Prefilled Syringe
Other: Intrauterine insemination or timed intercourse

First Posted Date: 2018-02-22

Last Posted Date: 2018-02-26

Lead Sponsor: Eastern Virginia Medical School

Target Recruit Count: 52

Registration Number: NCT03440359

Locations: 🇺🇸
Laurel A. Stadtmauer, MD, PhD, Norfolk, Virginia, United States

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