Double Ovarian Stimulation (DuoStim) Comparison of Triggers: Is There Any Advantage Using 3 Different Methods of Trigger for the Second Egg Collection in Predicted Low Responders?
Overview
- Phase
- Phase 4
- Intervention
- Triptorelin acetate (a-GnRH)
- Conditions
- IVF
- Sponsor
- Instituto Bernabeu
- Enrollment
- 165
- Locations
- 1
- Primary Endpoint
- number of retrieved oocytes
- Last Updated
- 4 years ago
Overview
Brief Summary
This study aims to investigate the efficacy of 3 different trigggers used for final maturation in the second ovarian stimulation in double stimulation protocol (aGnRH and hCG-rec vs. aGnRH only vs. hCG-rec only). The main objective is to compare the number of all retrieved oocytes and mature oocytes in patients predicted to be low ovarian responders.
This is a controlled randomized clinical study where 165 patients will be recruited.
Investigators
Andrea Bernabeu García
Co-Director
Instituto Bernabeu
Eligibility Criteria
Inclusion Criteria
- •BMI below 32
- •Presence of both ovaries
- •Indication for ovarian stimulation under Double Stimulation protocol (Duo Stim)
- •Meeting the criteria for Duo Stim
- •Medical history, history and physical examination without alterations
- •AMH and AFV results in accordnace to Poseidon classification group 3 or 4 no more than 6 months prior to signing the consent form
- •Ability to participate and comply with the study protocol.
- •To have given written consent
- •Normal karyotype and fragile X.
Exclusion Criteria
- •Non-compliance with instructions and/or non-formalization of consents or legal requirements for IVF.
- •Concurrent participation in another study
Arms & Interventions
a-GnRH
Administration of triptorelin acetate 0.2 mg for final oocyte maturation.
Intervention: Triptorelin acetate (a-GnRH)
hCG
Administration of coriogonadotropine alfa 250 mcg for final oocyte maturation.
Intervention: Ovitrelle® (hCG)
a-GnRH + hCG
Administration of triptorelin acetate 0.2 mg and coriogonadotropine alfa 250 mcg for final oocyte maturation.
Intervention: Decapeptyl 0.1 mg® (a-GnRH) and Ovitrelle® (hCG) used together
Outcomes
Primary Outcomes
number of retrieved oocytes
Time Frame: through study completion, usually will be evaluated on the last day of the treatment
number of oocytes retrieved in the second ovarian stimulation in the double stimulation protocol.
number of mature (MII) oocytes
Time Frame: through study completion, usually will be evaluated on the last day of the treatment
number of mature (MII) oocytes retrieved in the second ovarian stimulation in the double stimulation protocol.