Overview
Extracted from the stem, leaves, and flowers of Mentha piperita L. plant, peppermint oil (Mentha piperita) is a popular essential oil used in aromatherapy for both external and internal use. Mentha piperita is a hybrid of spearmint (Mentha spicata) and water mint (Mentha aquatica) . Medicinal use of herbal ingredients such as peppermint oil has a long history of treating digestive disorders and upper respiratory symptoms and cough . There are various over-the-counter and commercial uses of peppermint oil due to its carminative, cholagogue, antibacterial, secretolytic, and choleretic actions . Peppermint oil contains pulegone, which is a naturally-occurring pesticide . Other active constituents of peppermint oil include Menthol, menthone, cineol, and several other volatile oils . Peppermint oil is used as a flavouring agent in foods and fragrance in hygienic or cosmetic products, and as an anti-itch and cooling agent in topical pharmaceutical products. It is also an active ingredient in topical analgesics for the relief of joint and muscle pain. Peppermint oil can be applied topically to temporarily relieve tension-type headache. The use of peppermint oil in the management of irritable bowel syndrome (IBS) has been investigated in many clinical studies due to its relaxing effects on smooth muscle; however the evidence supporting this use is unclear. Due to its effectiveness in relaxing GI smooth muscle but ability to induce gastroesophageal reflux, enteric-coated formulations of peppermint oil has been established which bypass the upper GI tract unmetabolized, thereby facilitating its effect in the lower GI tract without effects in the upper tract . Peppermint oil is safe and well-tolerated at commonly recommended dosage .
Background
Extracted from the stem, leaves, and flowers of Mentha piperita L. plant, peppermint oil (Mentha piperita) is a popular essential oil used in aromatherapy for both external and internal use. Mentha piperita is a hybrid of spearmint (Mentha spicata) and water mint (Mentha aquatica) . Medicinal use of herbal ingredients such as peppermint oil has a long history of treating digestive disorders and upper respiratory symptoms and cough . There are various over-the-counter and commercial uses of peppermint oil due to its carminative, cholagogue, antibacterial, secretolytic, and choleretic actions . Peppermint oil contains pulegone, which is a naturally-occurring pesticide . Other active constituents of peppermint oil include Menthol, menthone, cineol, and several other volatile oils . Peppermint oil is used as a flavouring agent in foods and fragrance in hygienic or cosmetic products, and as an anti-itch and cooling agent in topical pharmaceutical products. It is also an active ingredient in topical analgesics for the relief of joint and muscle pain. Peppermint oil can be applied topically to temporarily relieve tension-type headache. The use of peppermint oil in the management of irritable bowel syndrome (IBS) has been investigated in many clinical studies due to its relaxing effects on smooth muscle; however the evidence supporting this use is unclear. Due to its effectiveness in relaxing GI smooth muscle but ability to induce gastroesophageal reflux, enteric-coated formulations of peppermint oil has been established which bypass the upper GI tract unmetabolized, thereby facilitating its effect in the lower GI tract without effects in the upper tract . Peppermint oil is safe and well-tolerated at commonly recommended dosage .
Indication
Indicated for the over-the-counter use for: -the symptomatic relief of minor spasms of the gastrointestinal tract, flatulence and abdominal pain, especially in patients with irritable bowel syndrome. -the temporary relief of itching associated with insect bites, eczema, minor burn, sunburn, minor skin irritations, minor cuts, scrapes, atopic dermatitis and other skin disorders. -the temporary symptomatic relief of mild joint and muscle pain as a local topical analgesic. -the temporary relief of tension-type headache.
Associated Conditions
- Colic
- Cough
- Flatulence
- Hypertonicity of the small intestine
- Irritable Bowel Syndrome (IBS)
- Mild pain
- Myalgia
- Nasal Congestion
- Gas pain
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
---|---|---|---|---|---|
2022/03/16 | Phase 1 | ENROLLING_BY_INVITATION | |||
2021/04/14 | Phase 1 | Recruiting | |||
2020/08/04 | Phase 1 | Withdrawn | |||
2017/09/28 | Phase 1 | Completed | Robert Shulman, M.D. | ||
2015/10/27 | Phase 3 | Terminated |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
---|---|---|---|---|---|
BIO EARTH MANUFACTURING (PTY) LTD | 70116-025 | TOPICAL | 0.8 g in 100 mL | 5/28/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
---|---|---|---|
No EMA approvals found for this drug. |
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
COLPERMIN CAPSULE 187mg | SIN13034P | CAPSULE, ENTERIC COATED | 187mg | 11/4/2004 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
---|---|---|---|---|---|
No NMPA approvals found for this drug. |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
---|---|---|---|---|---|
No PPB approvals found for this drug. |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
---|---|---|---|---|---|
KUGELMANS HERBAL HEAT LINIMENT bottle | 45809 | H.E Kugelman & Co | Medicine | A | 7/21/1993 |
Peppermint Oil | 273774 | Medicine | A | 4/4/2016 | |
NutriVital Activated Charcoal Plus | 323692 | Medicine | A | 9/17/2019 | |
Hold On Oil | 319839 | Medicine | A | 7/8/2019 | |
Natal Care | 395834 | Medicine | A | 9/12/2022 | |
Painaway Forte+ Heat Joint & Muscle Pain Relief Spray | 387805 | Medicine | A | 5/3/2022 | |
Fixbiome Fix No.1 Motility | 430696 | Medicine | A | 12/12/2023 | |
ATHELITE LAVA JOINT & MUSCLE PAIN RELIEF CREAM | 429411 | Medicine | A | 12/1/2023 | |
Athelite Infinity Queen Women’s Pain Relief Spray | 412170 | Medicine | A | 7/3/2023 | |
ARTHRITIC CREAM FORMULA jar/can | 71587 | Medicine | A | 10/20/1999 |