Cytarabine
- Generic Name
- Cytarabine
- Brand Names
- Cytosar, Vyxeos
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N3O5
- CAS Number
- 147-94-4
- Unique Ingredient Identifier
- 04079A1RDZ
- Background
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
- Indication
For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Cytarabine is indicated in combination with daunorubicin for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in adults and pediatric patients 1 year and older.
- Associated Conditions
- Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia, Acute Myeloid Leukemia With Myelodysplasia-Related Changes, Acute Promyelocytic Leukemia, Meningeal leukemia, Metastatic Malignant Neoplasm to the Leptomeninges, Non-Hodgkin's Lymphoma (NHL), Treatment-Related Acute Myeloid Leukemia, Blast phase Chronic myeloid leukemia
- Associated Therapies
- -
Chemotherapy and Bone Marrow Transplantation in Treating Patients Acute Myeloid With Leukemia or Myelodysplastic Syndrome
- Conditions
- First Posted Date
- 2004-05-24
- Last Posted Date
- 2012-08-07
- Lead Sponsor
- Barbara Ann Karmanos Cancer Institute
- Target Recruit Count
- 280
- Registration Number
- NCT00002547
- Locations
- ๐บ๐ธ
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
SWOG-9320 Combination Chemotherapy, Radiation Therapy, and Antiviral Therapy in Treating Patients With AIDS-Related Lymphoma
- Conditions
- Interventions
- Biological: bleomycin sulfateBiological: filgrastimDrug: cyclophosphamideDrug: cytarabineDrug: doxorubicin hydrochlorideDrug: etoposideDrug: leucovorin calciumDrug: methotrexateDrug: prednisoneDrug: trimethoprim-sulfamethoxazoleDrug: vincristine sulfateRadiation: radiation therapyDrug: Intrathecal cytarabine
- First Posted Date
- 2004-05-24
- Last Posted Date
- 2013-01-24
- Lead Sponsor
- SWOG Cancer Research Network
- Target Recruit Count
- 52
- Registration Number
- NCT00002571
- Locations
- ๐บ๐ธ
MBCCOP - University of South Alabama, Mobile, Alabama, United States
๐บ๐ธUSC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
๐บ๐ธJonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia
- Conditions
- First Posted Date
- 2004-05-24
- Last Posted Date
- 2021-10-14
- Lead Sponsor
- Rush University Medical Center
- Registration Number
- NCT00003405
- Locations
- ๐บ๐ธ
Rush-Riverside Cancer Center, Kankakee, Illinois, United States
๐บ๐ธCook County Hospital, Chicago, Illinois, United States
๐บ๐ธRush Cancer Institute, Chicago, Illinois, United States
Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma
- Conditions
- First Posted Date
- 2004-05-24
- Last Posted Date
- 2010-02-24
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 19
- Registration Number
- NCT00003187
- Locations
- ๐บ๐ธ
University of South Carolina School of Medicine, Columbia, South Carolina, United States
๐บ๐ธMemorial Sloan-Kettering Cancer Center, New York, New York, United States
๐บ๐ธWestern Pennsylvania Hospital, Pittsburgh, Pennsylvania, United States
Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2004-05-20
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- United Kingdom Children's Cancer Study Group
- Target Recruit Count
- 100
- Registration Number
- NCT00003423
- Locations
- ๐ฌ๐ง
Hospital for Sick Children NHS Trust, London, England, United Kingdom
Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid Leukemia
- First Posted Date
- 2004-05-20
- Last Posted Date
- 2014-07-28
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 35
- Registration Number
- NCT00004056
- Locations
- ๐บ๐ธ
University of Alabama Comprehensive Cancer Center, Birmingham, Alabama, United States
๐บ๐ธArizona Cancer Center, Tucson, Arizona, United States
๐บ๐ธNemours Children's Clinic, Jacksonville, Florida, United States
Gallium Nitrate in Treating Patients With AIDS-Related Non-Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2004-05-20
- Last Posted Date
- 2015-10-06
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 35
- Registration Number
- NCT00002578
- Locations
- ๐บ๐ธ
Albert Einstein Comprehensive Cancer Center, Bronx, New York, United States
๐บ๐ธRoswell Park Cancer Institute, Buffalo, New York, United States
๐บ๐ธUSC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia
- First Posted Date
- 2004-05-20
- Last Posted Date
- 2016-07-06
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 163
- Registration Number
- NCT00003700
- Locations
- ๐บ๐ธ
University of Illinois at Chicago Health Sciences Center, Chicago, Illinois, United States
๐บ๐ธUniversity of Chicago Cancer Research Center, Chicago, Illinois, United States
๐บ๐ธVeterans Affairs Medical Center - Chicago (Westside Hospital), Chicago, Illinois, United States
Chemotherapy and Biological Therapy in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
- Conditions
- Interventions
- First Posted Date
- 2004-04-30
- Last Posted Date
- 2012-07-30
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 90
- Registration Number
- NCT00003239
- Locations
- ๐บ๐ธ
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
Combination Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2004-04-29
- Last Posted Date
- 2013-12-18
- Lead Sponsor
- St. Luke's Medical Center
- Registration Number
- NCT00002481
- Locations
- ๐บ๐ธ
St. Luke's Medical Center, Milwaukee, Wisconsin, United States
Drug Development Updates
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