Caffeine

Generic Name: Caffeine

Brand Names: Anacin, Arthriten Inflammatory Pain, Ascomp, Bc Arthritis, Bc Original Formula, Cafcit, Diurex, Dvorah, Esgic, Exaprin, Excedrin, Excedrin Tension Headache, Fioricet, Fioricet With Codeine, Fiorinal, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Midol Complete, Midol Cramps & Bodyaches, Migergot, Norgesic, Norgesic Forte, Orbivan, Orphengesic, Pamprin Max Formula, Peyona, Stanback Headache Powder Reformulated Jan 2011, Trezix, Trianal, Trianal C, Triatec, Triatec-8, Vanatol, Vanatol S, Vanquish, Vivarin, Peyona (previously Nymusa), Gencebok

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₀N_₄O_₂

CAS Number: 58-08-2

Unique Ingredient Identifier: 3G6A5W338E

Background: Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to Theophylline and Theobromine. It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, whic...

Indication: Caffeine is indicated for the short term treatment of apnea of prematurity in infants and off label for the prevention and treatment of bronchopulmonary dysplasia caused by premature birth. In addition, it is indicated in combination with sodium benzoate to treat respiratory depression resulting from an overdose with CNS depressant drugs. Caffeine has a broa...

Associated Conditions: Acute Pain, Chronic Lung Disease of Prematurity, Common Cold, Dyspepsia, Fatigue, Fever, Flu caused by Influenza, Headache, Menstrual Pain, Myalgia, Pain, Pain caused by Rheumatism, Primary apnea of premature newborns, Respiratory Depression, Somnolence, Tension Headache, Toothache, Under-eyes Dark Circles, Vascular Headaches, Moderate Pain

Associated Therapies: Analgesia, Antacid therapy, Athletic Performance

Clinical Trials

Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean

Phase 4

Completed

Conditions: Post-Dural Puncture Headache

Interventions: Drug: Pregabalin 100Mg Oral Cap
Drug: Acetaminophen
Drug: Hydrocortisone
Other: oral fluids
Drug: Caffeine
Drug: Diclofenac

First Posted Date: 2019-04-10

Last Posted Date: 2019-11-12

Lead Sponsor: Cairo University

Target Recruit Count: 30

Registration Number: NCT03910088

Locations: 🇪🇬
Cairo University, Cairo, Zamalek, Egypt

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

Phase 1

Active, not recruiting

Conditions: Metastatic Melanoma
Advanced Solid Tumors

Interventions: Drug: losartan
Drug: rosuvastatin
Drug: bupropion immediate release (IR)
Drug: dextromethorphan
Drug: caffeine
Drug: modafinil
Drug: omeprazole
Drug: midazolam
Drug: encorafenib
Drug: binimetinib

First Posted Date: 2019-03-06

Last Posted Date: 2023-06-08

Lead Sponsor: Pfizer

Target Recruit Count: 56

Registration Number: NCT03864042

Locations: 🇨🇦
Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
🇺🇸
UC Irvine Health, Orange, California, United States
🇺🇸
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora, Colorado, United States

and more 26 locations

Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4

Phase 1

Completed

Conditions: Atopic Dermatitis

Interventions: Drug: Tralokinumab
Drug: Caffeine
Drug: Warfarin
Drug: Omeprazole
Drug: Metoprolol
Drug: Midazolam Hydrochloride

First Posted Date: 2018-06-14

Last Posted Date: 2024-10-26

Lead Sponsor: LEO Pharma

Target Recruit Count: 40

Registration Number: NCT03556592

Locations: 🇳🇱
LEO Pharma Investigational Site, Leiden, Netherlands

Drug-Drug Interaction (DDI) Study for TD-9855

Phase 1

Completed

Conditions: Drug Drug Interaction (DDI)

Interventions: Drug: TD-9855
Drug: Fluvoxamine
Drug: Itraconazole
Drug: Caffeine

First Posted Date: 2018-02-14

Last Posted Date: 2021-01-14

Lead Sponsor: Theravance Biopharma

Target Recruit Count: 41

Registration Number: NCT03432793

Locations: 🇺🇸
Celerion, Lincoln, Nebraska, United States

The Acute Effects of Caffeine on Exercise and Cognition

Phase 4

Completed

Conditions: Adult Population

Interventions: Behavioral: Moderate Intensity Exercise
Drug: Caffeine

First Posted Date: 2018-01-17

Last Posted Date: 2024-03-04

Lead Sponsor: Western University, Canada

Target Recruit Count: 64

Registration Number: NCT03400423

Locations: 🇨🇦
Western University, London, Ontario, Canada

A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia

Phase 4

Completed

Conditions: Anesthesia

Interventions: Drug: Placebo
Drug: Caffeine

First Posted Date: 2017-12-04

Last Posted Date: 2019-11-18

Lead Sponsor: University of Chicago

Target Recruit Count: 8

Registration Number: NCT03360903

Locations: 🇺🇸
The University of Chicago, Chicago, Illinois, United States

Intermittent Hypoxia and Caffeine in Infants Born Preterm

Phase 2

Completed

Conditions: Intermittent Hypoxia

Interventions: Drug: Placebos
Drug: Caffeine

First Posted Date: 2017-10-26

Last Posted Date: 2023-09-01

Lead Sponsor: Children's National Research Institute

Target Recruit Count: 170

Registration Number: NCT03321734

Locations: 🇺🇸
Children's National Medical Center/Children's Research Institute, Washington, District of Columbia, United States
🇺🇸
Loma Linda University Health System, Loma Linda, California, United States
🇺🇸
University of Massachusetss, Worcester, Massachusetts, United States

and more 12 locations