Overview
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. In August 2017, a combination antibacterial therapy under the market name vabomere was approved for treatment of adult patients with complicated urinary tract infections (cUTI). Vabomere consists of meropenem and Vaborbactam and is intravenously admininstered. The treatment aims to resolve infection-related symptoms and achieve negative urine culture, where the infections are proven or strongly suspected to be caused by susceptible bacteria.
Indication
For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (excluding vancomycin-resistant isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species; complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.
Associated Conditions
- Bacterial Infections
- Complicated Intra-Abdominal Infections (cIAIs)
- Meningitis, Bacterial
- Complicated Urinary Tract Infection caused by susceptible bacteria
- Complicated skin infection bacterial
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2018/08/24 | Phase 4 | Completed | |||
2018/08/14 | Phase 3 | Not yet recruiting | |||
2018/06/27 | N/A | UNKNOWN | |||
2018/06/01 | Phase 3 | Completed | |||
2018/04/25 | N/A | Completed | |||
2018/04/03 | Phase 2 | Completed | |||
2018/03/26 | Phase 3 | Completed | |||
2018/03/02 | Phase 4 | Completed | |||
2017/11/17 | Not Applicable | Completed | |||
2017/07/26 | Phase 2 | Completed |
FDA Drug Approvals
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