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Furosemide

Generic Name
Furosemide
Brand Names
Furoscix, Lasix
Drug Type
Small Molecule
Chemical Formula
C12H11ClN2O5S
CAS Number
54-31-9
Unique Ingredient Identifier
7LXU5N7ZO5

Overview

Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.

Background

Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.

Indication

Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients. Oral furosemide is indicated alone for the management of mild to moderate hypertension or severe hypertension in combination with other antihypertensive medications. Intravenous furosemide is indicated as adjunctive therapy in acute pulmonary edema when a rapid onset of diuresis is desired. Subcutaneous furosemide is indicated for the treatment of congestion due to fluid overload in adults with NYHA Class II/III chronic heart failure. This drug formulation is not indicated for emergency situations or in patients with acute pulmonary edema.

Associated Conditions

  • Acute Pulmonary Edema
  • Ascites
  • Body Fluid Retention
  • Edema
  • Hypertension
  • Mild to Moderate Hypertension
  • Chest congestion

FDA Approved Products

Furosemide
Manufacturer:Sagent Pharmaceuticals
Route:INTRAVENOUS, INTRAMUSCULAR
Strength:10 mg in 1 mL
Approved: 2021/03/01
NDC:25021-311
Furosemide
Manufacturer:Preferred Pharmaceuticals, Inc.
Route:ORAL
Strength:40 mg in 1 1
Approved: 2023/06/16
NDC:68788-6784
Furosemide
Manufacturer:PD-Rx Pharmaceuticals, Inc.
Route:ORAL
Strength:40 mg in 1 1
Approved: 2023/04/18
NDC:43063-716
Furosemide
Manufacturer:Amneal Pharmaceuticals LLC
Route:INTRAMUSCULAR, INTRAVENOUS
Strength:40 mg in 4 mL
Approved: 2024/01/19
NDC:70121-1164
Furosemide
Manufacturer:Rising Pharma Holdings, Inc.
Route:ORAL
Strength:80 mg in 1 1
Approved: 2023/06/09
NDC:64980-564

Singapore Approved Products

APO-FUROSEMIDE TABLET 40 mg
Manufacturer:APOTEX INC
Form:TABLET
Strength:40 mg
Online:Yes
Approved: 1988/03/14
Approval:SIN00088P
FUROSEMIDE-AFT SOLUTION FOR INJECTION 20MG/2ML
Manufacturer:Private Joint Stock Company "Pharmaceutical firm "Darnitsa"
Form:INJECTION, SOLUTION
Strength:20mg/2ml
Online:Yes
Approved: 2023/05/16
Approval:SIN16784P
FUROSEMIDE-BAXTER SOLUTION FOR INJECTION 20 MG/2 ML
Manufacturer:Baxter Pharmaceuticals India Private Limited
Form:INJECTION, SOLUTION
Strength:20 mg/2 mL
Online:Yes
Approved: 2017/11/23
Approval:SIN15366P
RASITOL TABLET 40MG
Manufacturer:Y.S.P. INDUSTRIES (M) SDN. BHD.
Form:TABLET
Strength:40mg
Online:Yes
Approved: 2012/01/09
Approval:SIN14074P
DIRINE INJECTION 20 mg/2 ml
Manufacturer:ATLANTIC LABORATORIES CORPN LTD
Form:INJECTION
Strength:20 mg/2 ml
Online:Yes
Approved: 1988/04/05
Approval:SIN00239P

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