Furosemide

Generic Name
Furosemide
Brand Names
Furoscix, Lasix
Drug Type
Small Molecule
Chemical Formula
C12H11ClN2O5S
CAS Number
54-31-9
Unique Ingredient Identifier
7LXU5N7ZO5
Background

Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrol...

Indication

Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients.
...

Associated Conditions
Acute Pulmonary Edema, Ascites, Body Fluid Retention, Edema, Hypertension, Mild to Moderate Hypertension, Chest congestion
Associated Therapies
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Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide

First Posted Date
2019-01-11
Last Posted Date
2019-03-22
Lead Sponsor
Akebia Therapeutics
Target Recruit Count
62
Registration Number
NCT03801759
Locations
🇨🇦

inVentiv Health Clinique Inc., Québec City, Quebec, Canada

Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach

First Posted Date
2018-12-11
Last Posted Date
2023-04-28
Lead Sponsor
Washington State University
Target Recruit Count
16
Registration Number
NCT03772262
Locations
🇺🇸

Washington State University, Spokane, Washington, United States

FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2018-11-06
Last Posted Date
2020-12-16
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
11
Registration Number
NCT03731117
Locations
🇫🇷

Hopital Bichat, Paris, France

🇫🇷

CH Cote Basque, Bayonne, France

🇫🇷

Hopital Saint Louis, Paris, France

An Investigational Study of Continuous 8-Hour Intravenous Administrations of BMS-986231 in Participants With Heart Failure and Reduced Heart Function Given a Standard Dose of Loop Diuretic

First Posted Date
2018-11-05
Last Posted Date
2021-02-26
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
23
Registration Number
NCT03730961
Locations
🇬🇧

Richmond Pharmacology, London, United Kingdom

🇬🇧

Glasgow Clinical Research Facility, Glasgow, United Kingdom

Furosemide and Coarctation Surgery Lung Complications

Phase 2
Completed
Conditions
Interventions
First Posted Date
2017-12-07
Last Posted Date
2017-12-27
Lead Sponsor
Cairo University
Target Recruit Count
56
Registration Number
NCT03364842
Locations
🇪🇬

Cairo university, Cairo, Egypt

Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2017-12-05
Last Posted Date
2023-08-30
Lead Sponsor
Thomas Jefferson University
Target Recruit Count
18
Registration Number
NCT03362515
Locations
🇺🇸

Thomas Jefferson University Department of Otolaryngology, Philadelphia, Pennsylvania, United States

This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men

First Posted Date
2017-10-11
Last Posted Date
2023-11-07
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
45
Registration Number
NCT03307252
Locations
🇩🇪

CTC North GmbH & Co. KG, Hamburg, Hamburg, Germany

TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure

Phase 3
Completed
Conditions
Interventions
First Posted Date
2017-09-28
Last Posted Date
2022-08-19
Lead Sponsor
Duke University
Target Recruit Count
2859
Registration Number
NCT03296813
Locations
🇺🇸

Weill Cornell Medical College, New York, New York, United States

🇺🇸

VA Medical Center/University of Maryland, Baltimore, Maryland, United States

🇺🇸

Drexel University College of Medicine, Philadelphia, Pennsylvania, United States

and more 57 locations

SGLT2 Inhibition in Combination With Diuretics in Heart Failure

First Posted Date
2017-07-21
Last Posted Date
2021-06-30
Lead Sponsor
University of Dundee
Target Recruit Count
23
Registration Number
NCT03226457
Locations
🇬🇧

University of Dundee, Ninewells Hospital and Medical School, Dundee, Angus, United Kingdom

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