Furosemide

Generic Name: Furosemide

Brand Names: Furoscix, Lasix

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₁ClN_₂O_₅S

CAS Number: 54-31-9

Unique Ingredient Identifier: 7LXU5N7ZO5

Background: Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrol...

Indication: Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients.
...

Associated Conditions: Acute Pulmonary Edema, Ascites, Body Fluid Retention, Edema, Hypertension, Mild to Moderate Hypertension, Chest congestion

Associated Therapies: -

Clinical Trials

A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers

Phase 1

Completed

Conditions: Drug Drug Interaction

Interventions: Drug: Nitisinone in Arm A
Drug: Furosemide
Drug: Nitisinone in Arm B
Drug: Tolbutamide
Drug: Metoprolol
Drug: Chlorzoxazone

First Posted Date: 2017-04-06

Last Posted Date: 2017-08-10

Lead Sponsor: Swedish Orphan Biovitrum

Target Recruit Count: 36

Registration Number: NCT03103568

Locations: 🇩🇪
PAREXEL EPCU Berlin, Berlin, Germany

The Effect of Diuretics on Mineral and Bone Disorder in Chronic Kidney Disease Patients

Not Applicable

Conditions: Chronic Kidney Disease
Secondary Hyperparathyroidism

Interventions: Drug: Hydrochlorothiazide
Drug: Furosemide

First Posted Date: 2017-03-17

Last Posted Date: 2017-10-26

Lead Sponsor: University of Sao Paulo General Hospital

Target Recruit Count: 52

Registration Number: NCT03082742

Locations: 🇧🇷
Hospital das Clinicas, Sao Paulo, SP, Brazil

A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects

Phase 1

Completed

Conditions: Diabetes
Healthy

Interventions: Drug: Furosemide
Drug: Rosuvastatin
Drug: SNAC
Drug: Semaglutide

First Posted Date: 2017-01-05

Last Posted Date: 2017-12-20

Lead Sponsor: Novo Nordisk A/S

Target Recruit Count: 41

Registration Number: NCT03010475

Locations: 🇬🇧
Novo Nordisk Investigational Site, Harrow, United Kingdom

Effects of Aminophylline on Renal Function and Urine Volume of AKI Patient

Early Phase 1

Conditions: Acute Kidney Injury

Interventions: Drug: aminophylline
Drug: normal saline
Drug: frusemide

First Posted Date: 2016-12-06

Last Posted Date: 2016-12-06

Lead Sponsor: Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Target Recruit Count: 60

Registration Number: NCT02983422

Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy

Phase 4

Completed

Conditions: Cystoscopy

Interventions: Drug: Normal Saline
Drug: furosemide

First Posted Date: 2016-11-09

Last Posted Date: 2019-03-28

Lead Sponsor: University of South Florida

Target Recruit Count: 150

Registration Number: NCT02960412

Locations: 🇺🇸
Tampa General Hospital, Tampa, Florida, United States

Efficacy of Furosemide Versus Vascular Filling in Patients With Acute Myocardial Infarction

Phase 3

Conditions: Acute Myocardial Infarction With Right Ventricular Extension

Interventions: Drug: Furosemide
Drug: Placebo furosemide
Drug: Placebo filling
Drug: Vascular filling

First Posted Date: 2016-09-19

Last Posted Date: 2016-09-19

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 88

Registration Number: NCT02905760

Locations: 🇫🇷
Henri Mondor Hospital, Creteil, France

Specificity of Dyspnoea Relief With Inhaled Furosemide

Phase 1

Completed

Conditions: Dyspnea

Interventions: Drug: Furosemide
Drug: Saline

First Posted Date: 2016-08-29

Last Posted Date: 2016-08-29

Lead Sponsor: Oxford Brookes University

Target Recruit Count: 16

Registration Number: NCT02881866

Locations: 🇬🇧
Oxford Brookes University, Oxford, Oxfordshire, United Kingdom

Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot

Phase 1

Completed

Conditions: Acute Heart Failure

Interventions: Drug: Furosemide

First Posted Date: 2016-08-24

Last Posted Date: 2019-03-15

Lead Sponsor: Adrian Hernandez

Target Recruit Count: 40

Registration Number: NCT02877095

Locations: 🇺🇸
Emory University Hospital, Atlanta, Georgia, United States
🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Metro Health System, Cleveland, Ohio, United States

and more 2 locations

Transporter Cocktail Mutual Interaction

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Furosemide
Drug: Metformin
Drug: Digoxin
Drug: Metformin hydrochloride
Drug: Rosuvastatin

First Posted Date: 2016-08-03

Last Posted Date: 2023-11-07

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 30

Registration Number: NCT02854527

Locations: 🇩🇪
Humanpharmakologisches Zentrum Biberach, Biberach, Germany

Transfusion-Associated Circulatory Overload Best Eliminated With Lasix

Early Phase 1

Completed

Conditions: Transfusion-associated Circulatory Overload

Interventions: Drug: Normal Saline
Drug: Furosemide

First Posted Date: 2016-06-16

Last Posted Date: 2017-06-26

Lead Sponsor: Sunnybrook Health Sciences Centre

Target Recruit Count: 80

Registration Number: NCT02802696

Locations: 🇨🇦
Canadian Blood Services, Toronto, Ontario, Canada
🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
🇨🇦
University Health Network, Toronto, Ontario, Canada

Drug Development Updates

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