Furosemide

Generic Name: Furosemide

Brand Names: Furoscix, Lasix

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₁ClN_₂O_₅S

CAS Number: 54-31-9

Unique Ingredient Identifier: 7LXU5N7ZO5

Background: Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrol...

Indication: Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients.
...

Associated Conditions: Acute Pulmonary Edema, Ascites, Body Fluid Retention, Edema, Hypertension, Mild to Moderate Hypertension, Chest congestion

Associated Therapies: -

Clinical Trials

Ultrafiltration (Aquapheresis) in Patients With Leukemia and Severe Fluid Overload

Not Applicable

Withdrawn

Conditions: Leukemia

Interventions: Procedure: Aquapheresis
Drug: Furosemide

First Posted Date: 2012-01-11

Last Posted Date: 2013-04-05

Lead Sponsor: M.D. Anderson Cancer Center

Registration Number: NCT01508260

Aerosol Inhalation Treatment for Dyspnea

Phase 1

Completed

Conditions: Healthy
Dyspnea

Interventions: Drug: Furosemide
Drug: Saline

First Posted Date: 2011-09-27

Last Posted Date: 2017-06-14

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 24

Registration Number: NCT01440764

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Troponin I Release After High Diuretic Doses

Phase 4

Completed

Conditions: ADHF

Interventions: Drug: Furosemide

First Posted Date: 2011-08-17

Last Posted Date: 2011-11-01

Lead Sponsor: University of Palermo

Target Recruit Count: 60

Registration Number: NCT01419132

Locations: 🇮🇹
GF Ingrasasia Hospital, Palermo, Italy
🇮🇹
Department of Internal and Specialty Medicine, Palermo, Italy
🇮🇹
Gaspare PArrinello, Palermo, Italy

Trial on Treatment With Inhaled Furosemide of Preterm and Term Neonates With Transient Tachypnoea

Phase 2

Completed

Conditions: Transient Tachypnoea of the Newborn

Interventions: Drug: Saline 0,9%
Drug: Furosemide

First Posted Date: 2011-08-02

Last Posted Date: 2015-09-23

Lead Sponsor: University of Cologne

Target Recruit Count: 20

Registration Number: NCT01407848

Locations: 🇩🇪
Children´s Hospital University of Cologne, Cologne, NRW, Germany

Measurement of Kidney Blood Flow and Oxygen Levels by MRI

Not Applicable

Completed

Conditions: Chronic Kidney Disease

Interventions: Other: Placebo
Drug: Furosemide

First Posted Date: 2011-03-21

Last Posted Date: 2018-09-07

Lead Sponsor: Wake Forest University

Target Recruit Count: 10

Registration Number: NCT01318967

Locations: 🇺🇸
Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury

Not Applicable

Completed

Conditions: Acute Kidney Failure

Interventions: Drug: Furosemide

First Posted Date: 2011-01-12

Last Posted Date: 2023-07-07

Lead Sponsor: University of Chicago

Target Recruit Count: 96

Registration Number: NCT01275729

Locations: 🇺🇸
Johns Hopkins Medicine, Baltimore, Maryland, United States
🇺🇸
University of California-San Francisco, San Francisco, California, United States
🇺🇸
University of Chicago, Chicago, Illinois, United States

and more 1 locations

Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers

Phase 4

Withdrawn

Conditions: Healthy Male and Female Volunteers

Interventions: Drug: Furosemide
Drug: aminohippurate sodium

First Posted Date: 2010-07-02

Last Posted Date: 2022-07-01

Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Registration Number: NCT01156220

Locations: 🇩🇪
Clinical Trial Center North, Hamburg, Germany

Intra-Renal Therapy of Diuretic Unresponsive Acute Kidney Injury

Phase 4

Withdrawn

Conditions: Kidney Failures, Acute

Interventions: Drug: Intra-Renal Fenoldopam
Drug: Furosemide

First Posted Date: 2010-02-23

Last Posted Date: 2016-03-28

Lead Sponsor: Southeast Renal Research Institute

Registration Number: NCT01073189

Locations: 🇺🇸
Erlanger Medical Center, Chattanooga, Tennessee, United States

The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients

Not Applicable

Conditions: Intra-Abdominal Hypertension

Interventions: Drug: furosemide

First Posted Date: 2010-02-19

Last Posted Date: 2010-02-22

Lead Sponsor: Ziekenhuis Netwerk Antwerpen (ZNA)

Target Recruit Count: 30

Registration Number: NCT01072071

Locations: 🇧🇪
ZNA Stuivenberg Intensive Care Unit, Antwerpen, Belgium

Furosemide vs Placebo for Brain Relaxation

Not Applicable

Terminated

Conditions: Brain Swelling
Brain Edema
Dehydration

Interventions: Drug: Placebo
Drug: Furosemide

First Posted Date: 2010-01-22

Last Posted Date: 2013-08-02

Lead Sponsor: Northwestern University

Target Recruit Count: 23

Registration Number: NCT01054404

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States

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