Proflavine

Generic Name: Proflavine

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₁N_₃

CAS Number: 92-62-6

Unique Ingredient Identifier: CY3RNB3K4T

Background: 3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings.

Indication: Topical antiseptic used mainly in wound dressings.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Acceptability and Performance of a Mobile Optical Biopsy Technology for Gastrointestinal Cancer Screening

Phase 2

Completed

Conditions: Suspected or Known Squamous Cell Neoplasia
Prior History of Squamous Cell Dysplasia and /or Neoplasia

Interventions: Drug: Proflavine
Device: Mobile, Augmented High Resolution Microendoscope

First Posted Date: 2022-05-31

Last Posted Date: 2022-06-09

Lead Sponsor: Anandasabapathy, Sharmila, M.D.

Target Recruit Count: 41

Registration Number: NCT05396781

Locations: 🇺🇸
Baylor College of Medicine, Houston, Texas, United States
🇧🇷
University of Sao Paulo, São Paulo, Sao Paulo, Brazil

Low-Cost Imaging for Cervical Cancer Prevention in the Texas Lower Rio Grande Valley

Early Phase 1

Active, not recruiting

Conditions: Malignant Neoplasms of Female Genital Organs

Interventions: Drug: Proflavine
Procedure: High-Resolution Microendoscopy (HRME)

First Posted Date: 2016-03-21

Last Posted Date: 2023-08-09

Lead Sponsor: The University of Texas Medical Branch, Galveston

Target Recruit Count: 150

Registration Number: NCT02714439

Locations: 🇺🇸
University of Texas Medical Branch Cancer Stop McAllen Clinic, McAllen, Texas, United States

Use of High-Resolution Microendoscopy (HRME) in Patients With Cervical Dysplasia

Early Phase 1

Completed

Conditions: Cervical Cancer

Interventions: Drug: Proflavine
Device: HRME Imaging
Behavioral: Phone Call
Procedure: Colposcopy
Drug: Acetic Acid

First Posted Date: 2015-04-20

Last Posted Date: 2021-05-28

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 50

Registration Number: NCT02420665

Locations: 🇺🇸
Lyndon B. Johnson General Hospital, Houston, Texas, United States
🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Use of High-Resolution Microendoscopy (HRME) in Patients With Adenocarcinoma In-Situ (AIS) of the Cervix

Not Applicable

Completed

Conditions: Cervix Carcinoma

Interventions: Drug: Proflavine
Procedure: High-Resolution Microendoscopy (HRME) Imaging

First Posted Date: 2014-08-01

Last Posted Date: 2022-07-25

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 9

Registration Number: NCT02206048

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

High-Resolution Microendoscopy to Guide Hysteroscopic Tumor Resection

Phase 2

Withdrawn

Conditions: Uterine Cancer

Interventions: Procedure: High-Resolution Microendoscopy Imaging
Drug: Proflavine

First Posted Date: 2014-03-26

Last Posted Date: 2015-04-08

Lead Sponsor: M.D. Anderson Cancer Center

Registration Number: NCT02095847

Evaluation of a Miniaturized Microscope Device for the Detection of Esophageal Squamous Cell Cancer

Early Phase 1

Completed

Conditions: Squamous Cell Cancer

Interventions: Drug: proflavine

First Posted Date: 2011-06-29

Last Posted Date: 2016-01-11

Lead Sponsor: Anandasabapathy, Sharmila, M.D.

Target Recruit Count: 70

Registration Number: NCT01384708

Locations: 🇺🇸
Mount Sinai Medical Center, New York, New York, United States

Endoscopic Multispectral Imaging for the Early Detection of Barrett's Neoplasia

Early Phase 1

Completed

Conditions: Barrett's Esophagus
Intraepithelial Neoplasia

Interventions: Drug: proflavine

First Posted Date: 2011-06-29

Last Posted Date: 2016-01-11

Lead Sponsor: Anandasabapathy, Sharmila, M.D.

Target Recruit Count: 30

Registration Number: NCT01384864

Locations: 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States

Wide-Field and High Resolution in Vivo Imaging in Visualizing Lesions in Patients with Oral Neoplasia Undergoing Surgery

Early Phase 1

Recruiting

Conditions: Oral Cavity Neoplasm

Interventions: Procedure: High-Resolution Microendoscopy
Procedure: Multispectral Imaging
Drug: Proflavine

First Posted Date: 2011-01-04

Last Posted Date: 2024-10-17

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 275

Registration Number: NCT01269190

Locations: 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States

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