Caspofungin

Generic Name: Caspofungin

Brand Names: Cancidas, Cancidas (previously Caspofungin MSD)

Drug Type: Small Molecule

Chemical Formula: C_₅₂H_₈₈N_₁₀O_₁₅

CAS Number: 162808-62-0

Unique Ingredient Identifier: F0XDI6ZL63

Background: Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.

Indication: For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.

Associated Conditions: Abscess, Intra-Abdominal, Candidemia, Esophageal Candidiasis, Fungal Infections, Invasive Aspergillosis, Oropharyngeal Candidiasis, Peritonitis, Pleural space infections

Clinical Trials

Pharmacokinetics of Caspofungin (Cancidas ®) Given Intravenously as Therapy to Patients With an Invasive Fungal Infection in the Intensive Care Unit - a Search for Co-variates

Completed

Conditions: Invasive Fungal Infection

Interventions: Drug: caspofungin

First Posted Date: 2012-02-15

Last Posted Date: 2020-12-01

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 20

Registration Number: NCT01533558

Locations: 🇳🇱
Canisius Wilhelmina Hospital (CWZ), Nijmegen, Netherlands
🇳🇱
Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
🇳🇱
University Medical Centre Utrecht, Utrecht, Netherlands

and more 1 locations

Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant

Phase 3

Completed

Conditions: Fungal Infection
Hematopoietic and Lymphoid Cell Neoplasm

Interventions: Drug: Caspofungin Acetate
Drug: Fluconazole
Other: Laboratory Biomarker Analysis
Drug: Voriconazole

First Posted Date: 2012-01-04

Last Posted Date: 2024-10-16

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 292

Registration Number: NCT01503515

Locations: 🇺🇸
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States
🇺🇸
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States
🇨🇦
Hospital for Sick Children, Toronto, Ontario, Canada

and more 46 locations

Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease

Phase 4

Conditions: Invasive Pulmonary Aspergillosis
Chronic Obstructive Pulmonary Disease

Interventions: Drug: caspofungin

First Posted Date: 2011-12-26

Last Posted Date: 2014-01-23

Lead Sponsor: The First Affiliated Hospital of Guangzhou Medical University

Target Recruit Count: 40

Registration Number: NCT01499433

Locations: 🇨🇳
Guangzhou Institute of Respiratory Diseases, Guangzhou, Guangdong, China

Pharmacokinetic, Safety and Efficacy of Intermittent Application of Caspofungin for Antifungal Prophylaxis

Phase 2

Completed

Conditions: Fungal Infection

Interventions: Drug: caspofungin

First Posted Date: 2011-03-18

Last Posted Date: 2014-01-09

Lead Sponsor: Werner J. Heinz

Target Recruit Count: 25

Registration Number: NCT01318148

Locations: 🇩🇪
University of Wuerzburg Medical Centre, Department of Internal Medicine II, Wuerzburg, Germany

Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia

Phase 3

Completed

Conditions: Acute Myeloid Leukemia
Adult Acute Monoblastic Leukemia
Adult Acute Monocytic Leukemia
Adult Acute Myeloid Leukemia in Remission
Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With Maturation
Adult Acute Myeloid Leukemia With Minimal Differentiation
Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1
Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A

Interventions: Drug: Fluconazole
Drug: Caspofungin Acetate
Other: Laboratory Biomarker Analysis

First Posted Date: 2011-03-03

Last Posted Date: 2021-03-30

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 517

Registration Number: NCT01307579

Locations: 🇺🇸
Valley Children's Hospital, Madera, California, United States
🇺🇸
Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia, United States
🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States

and more 176 locations