Amlodipine
- Generic Name
- Amlodipine
- Brand Names
- Amlobenz, Azor, Caduet, Dafiro, Exforge, Exforge Hct, Katerzia, Lotrel, Norliqva, Norvasc, Prestalia, Tribenzor, Twynsta, Viacoram
- Drug Type
- Small Molecule
- Chemical Formula
- C20H25ClN2O5
- CAS Number
- 88150-42-9
- Unique Ingredient Identifier
- 1J444QC288
- Background
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnorma...
- Indication
Amlodipine may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of the following conditions :
• Hypertension
• Coronary artery disease
• Chronic stable angina
• Vasospastic angina (Prinzmetal’s or Variant angina)
...
- Associated Conditions
- Cardiovascular Events, Chronic Stable Angina Pectoris, Coronary Artery Disease (CAD), Homozygous Familial Hypercholesterolaemia (HoFH), Hypertension, Hypertension, Essential Hypertension, Mixed Dyslipidemias, Primary Hypercholesterolemia, Vasospastic Angina
- Associated Therapies
- -
Manidipine Versus Amlodipine in Patients With Hypertension
- First Posted Date
- 2017-04-10
- Last Posted Date
- 2020-09-04
- Lead Sponsor
- Korea University Guro Hospital
- Target Recruit Count
- 46
- Registration Number
- NCT03106597
- Locations
- 🇰🇷
Yonsei University Wonju Hospital, Wonju, Korea, Republic of
🇰🇷Yonsei University Severance Hospital, Seoul, Korea, Republic of
🇰🇷Korea University Guro Hospital, Seoul, Korea, Republic of
Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function
- Conditions
- Interventions
- First Posted Date
- 2017-03-17
- Last Posted Date
- 2023-03-09
- Lead Sponsor
- Ludwig-Maximilians - University of Munich
- Target Recruit Count
- 101
- Registration Number
- NCT03082014
- Locations
- 🇩🇪
Insitute for Stroke and Dementia Research, Munich, Germany
🇳🇱Maastricht University Medical Center, Maastricht, Netherlands
🇬🇧Centre for Clinical Brain Sciences, Edinburgh, Scotland, United Kingdom
Efficacy of Olmesartan on Cerebral Glucose Metabolism, Vascular Inflammation and Adipose Tissue
- Conditions
- Interventions
- First Posted Date
- 2016-12-19
- Last Posted Date
- 2016-12-20
- Lead Sponsor
- Kurume University
- Target Recruit Count
- 100
- Registration Number
- NCT02996916
- Locations
- 🇯🇵
Kurume University Hospital, Kurume, Japan
Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension
- First Posted Date
- 2016-11-25
- Last Posted Date
- 2020-01-14
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 104
- Registration Number
- NCT02973035
- Locations
- 🇰🇷
Busan University Hospital, Busan, Korea, Republic of
🇰🇷Chungnam University Hospital, Daejeon, Korea, Republic of
🇰🇷Busan Baik Hospital, Busan, Korea, Republic of
An Efficacy and Safety Study Evaluating the Fixed-Dose Combination of Candesartan Plus Amlodipine in Participants With Mild/Moderate Essential Hypertension
- Conditions
- Interventions
- First Posted Date
- 2016-11-21
- Last Posted Date
- 2017-06-09
- Lead Sponsor
- Takeda
- Registration Number
- NCT02969265
- Locations
- 🇨🇳
The Xiangya Hospitalof Central South University, Changsha, Hunan, China
🇨🇳People's Hospital of Wuhan University, Wuhan, Hubei, China
🇨🇳Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
Comparison of Efficacy and Safety of Combination Therapy and Monotherapy of Candesartan and Amlodipine for Dose-Finding in Patients With Essential Hypertension
- Conditions
- Interventions
- First Posted Date
- 2016-10-26
- Last Posted Date
- 2016-11-22
- Lead Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
- Target Recruit Count
- 392
- Registration Number
- NCT02944734
- Locations
- 🇰🇷
Kyungpook National University Hospital, Joong-gu, Daegu, Korea, Republic of
🇰🇷Catholic University of Korea Bucheon St. Mary's Hospital, Wonmi-gu, Bucheon, Korea, Republic of
🇰🇷Inje University Busan Paik Hospital, Busanjin-gu, Busan, Korea, Republic of
Nifedipine GITS and Amlodipine Besylate on Recovery of Blood Pressure Rhythm and Arterial Stiffness
- First Posted Date
- 2016-10-21
- Last Posted Date
- 2022-04-29
- Lead Sponsor
- Jing Liu
- Target Recruit Count
- 99
- Registration Number
- NCT02940548
- Locations
- 🇨🇳
Peking University People's Hospital, Beijing, China
Study of Multiple Oral Dosing to Evaluate the Safety and the Pharmacokinetic Drug-drug Interaction of Telmisartan/Amlodipine and Rosuvastatin in Healthy Male Volunteers
- Conditions
- Interventions
- First Posted Date
- 2016-10-14
- Last Posted Date
- 2016-10-14
- Lead Sponsor
- Daewon Pharmaceutical Co., Ltd.
- Target Recruit Count
- 71
- Registration Number
- NCT02933658
Bariatric Surgery and Pharmacokinetics of Amlodipine
- Conditions
- First Posted Date
- 2016-09-16
- Last Posted Date
- 2023-07-21
- Lead Sponsor
- Norwegian University of Science and Technology
- Target Recruit Count
- 12
- Registration Number
- NCT02904291
- Locations
- 🇳🇴
St. Olavs University Hospital, Trondheim, Norway
Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea
- Conditions
- Interventions
- First Posted Date
- 2016-09-12
- Last Posted Date
- 2018-06-14
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Target Recruit Count
- 69
- Registration Number
- NCT02896621
- Locations
- 🇧🇷
Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Drug Development Updates
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