Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Managing Agitated Delirium with Neuroleptics and Anti-Epileptics As a Neuroleptic Sparing Strategy
- Conditions
- Interventions
- First Posted Date
- 2022-06-24
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 30
- Registration Number
- NCT05431595
- Locations
- 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
Drug-drug Interaction Between Ciprofol and Mefanamic Acid or Valproate
- First Posted Date
- 2022-01-06
- Last Posted Date
- 2022-07-14
- Lead Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
- Target Recruit Count
- 41
- Registration Number
- NCT05181007
- Locations
- 🇨🇳
The second affiliated hospital Zhejiang University School of Medicine, Hanzhou, China
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients
- Conditions
- Interventions
- First Posted Date
- 2020-08-28
- Last Posted Date
- 2021-10-29
- Lead Sponsor
- Westat
- Registration Number
- NCT04531592
- Locations
- 🇺🇸
University of Texas Southwest, Dallas, Texas, United States
🇺🇸University of Colorado - Denver, Denver, Colorado, United States
🇺🇸University of California San Francisco, San Francisco, California, United States
Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium
- Conditions
- Interventions
- First Posted Date
- 2020-08-14
- Last Posted Date
- 2023-03-31
- Lead Sponsor
- University of Miami
- Registration Number
- NCT04513314
Mood Stabilizer-induced Metabolic Abnormalities in Bipolar Disorder
- First Posted Date
- 2020-07-24
- Last Posted Date
- 2020-07-24
- Lead Sponsor
- National Cheng-Kung University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT04486092
- Locations
- 🇨🇳
National Cheng Kung University (NCKU) Hospital, Tainan, Taiwan
Valproic Acid in Treating Cyanotic Breath Holding Spells
- First Posted Date
- 2020-07-23
- Last Posted Date
- 2020-07-23
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 150
- Registration Number
- NCT04482764
- Locations
- 🇪🇬
Assiut University Hospitals, Faculty of Medicine, Assiut, Egypt
Valproic Acid in Combination With Bevacizumab and Oxaliplatin/Fluoropyrimidine Regimens in Patients With Ras-mutated Metastatic Colorectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2020-03-17
- Last Posted Date
- 2023-11-13
- Lead Sponsor
- National Cancer Institute, Naples
- Target Recruit Count
- 200
- Registration Number
- NCT04310176
- Locations
- 🇮🇹
Istituto Tumori di Napoli - Fondazione G. Pascale, Napoli, Campania, Italy
Sleep Architecture in Valproate-induced Nocturnal Enuresis in Primary School and Preschool Children.
- Conditions
- Interventions
- First Posted Date
- 2019-12-10
- Last Posted Date
- 2020-05-07
- Lead Sponsor
- Mansoura University Hospital
- Target Recruit Count
- 260
- Registration Number
- NCT04191863
- Locations
- 🇪🇬
Mansoura University Hospital, Mansoura, Egypt
Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures
- Conditions
- Interventions
- First Posted Date
- 2019-05-07
- Last Posted Date
- 2022-02-17
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Target Recruit Count
- 103
- Registration Number
- NCT03940326
- Locations
- 🇮🇷
Bu Ali Sina Hospital, Sari, Mazandaran, Iran, Islamic Republic of
VPA Expanded UCB Transplantation for Treatment of Patients With Hematological Malignancies
- Conditions
- Interventions
- First Posted Date
- 2019-03-22
- Last Posted Date
- 2021-05-24
- Lead Sponsor
- Alla Keyzner
- Target Recruit Count
- 7
- Registration Number
- NCT03885947
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Drug Development Updates
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