Prostaglandin E2

Systematic review and meta-analysis of split-mouth randomized clinical trials on the effectiveness of photobiomodulation with low-level lasers in accelerating orthodontic tooth movement.

Exploratory study (ChiCTR2000035740) enrolled patients with haematologic malignancies and SR-aGVHD from 7 Chinese centres. Patients were randomized 1:1 into MSC or control groups. Inclusion criteria: age 13-70, first allogeneic haematopoietic stem cell transplantation, SR-aGVHD grade II+, treatable within 3 days, written informed consent. Exclusion criteria: life-threatening complications, active malignant solid tumours, severe allergies, mental/neurological disorders. MSC group received hUC-MSCs PLEB001, control group received placebo. Primary endpoint: ORR at d28. Secondary endpoints: ORR at d56, DCR rate, CR rate at d28/d56, OS. Safety endpoints: AEs, SAEs, infusion toxicity. Statistical analysis: R, SAS, SPSS. Post-hoc analyses: ORR, DCR, CR rate, OS, FFS, cumulative incidence of cGVHD.

CBD enhances cell viability, reduces ROS, lipid peroxidation, and LDH release in UV-exposed keratinocytes and melanocytes. It also upregulates NRF-2, HOMX1, and PPARγ, and downregulates NF-κB and MMP-9 in various cell types. CBD shows anti-inflammatory effects in TNF-α and poly-(I:C)-treated HaCaT cells, and reduces paw edema in carrageenan-induced inflammation in rats and mice. Clinical studies indicate CBD improves psoriasis, atopic dermatitis, and acne symptoms, enhances wound healing, and combats aging effects.

A pilot study on anakinra, an IL-1 antagonist, for endometriosis-related pain shows potential benefits in reducing pain scores and inflammatory markers, with no significant impact on menstrual cycles, suggesting it could be a non-hormonal, fertility-preserving treatment option for endometriosis.

Satellite cells are crucial for skeletal muscle regeneration, with studies highlighting their role in self-renewal and differentiation. Research explores intrinsic changes and extrinsic influences on myogenic stem cell function during aging, and the regulation of satellite cell quiescence during regeneration. Key findings include the indispensable role of Pax7-expressing satellite cells, asymmetric self-renewal and commitment in muscle, and the impact of the aged niche on muscle stem cell quiescence. Advances in understanding satellite cell behavior, isolation techniques, and their therapeutic potential in muscle disorders are also discussed.