Prostaglandin E2
- Generic Name
- Prostaglandin E2
- Brand Names
- Cervidil, Prepidil, Prostin E2
- Drug Type
- Small Molecule
- Chemical Formula
- C20H32O5
- CAS Number
- 363-24-6
- Unique Ingredient Identifier
- K7Q1JQR04M
- Background
Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
- Indication
For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first d...
- Associated Conditions
- Gestational Trophoblastic Neoplasia
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion, Uterus evacuation
Prostin and Propess in Induction of Labor
- First Posted Date
- 2012-07-09
- Last Posted Date
- 2014-02-06
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 200
- Registration Number
- NCT01635439
- Locations
- 🇸🇦
NWAFH, North west Armed Forces Hospital, Tabuk, Saudi Arabia
Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy
- First Posted Date
- 2012-06-15
- Last Posted Date
- 2012-08-07
- Target Recruit Count
- 30
- Registration Number
- NCT01620814
- Locations
- 🇹🇷
Zekai Tahir Burak Women Health Education Research Hospital, Ankara, Turkey
Prostaglandin E2 in Migraine Suffers Without Aura.
- Conditions
- Interventions
- First Posted Date
- 2011-06-29
- Last Posted Date
- 2011-11-09
- Lead Sponsor
- Troels Wienecke
- Target Recruit Count
- 12
- Registration Number
- NCT01384812
- Locations
- 🇩🇰
Danish Headache Center, Glostrup, Denmark
Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction
- Conditions
- Interventions
- First Posted Date
- 2010-08-27
- Last Posted Date
- 2012-08-23
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 170
- Registration Number
- NCT01190163
- Locations
- 🇧🇷
Hospital Maternidade Leonor Mendes de Barros, São Paulo, Brazil
🇧🇷Hospital M Boi Mirim, São Paulo, Brazil
🇧🇷Hospital Municipal Universitário - Faculdade de Medicina do ABC, São Bernardo, São Paulo, Brazil
Feasibility and Acceptability of the Combination of Propess and AN24 Monica for Outpatient Labour Induction (PRAM)
- Conditions
- Interventions
- First Posted Date
- 2009-12-07
- Last Posted Date
- 2012-01-06
- Lead Sponsor
- Liverpool Women's NHS Foundation Trust
- Target Recruit Count
- 70
- Registration Number
- NCT01026948
- Locations
- 🇬🇧
Liverpool Women's NHS Foundation Trust, Liverpool, Merseyside, United Kingdom
Labour Induction With Misoprostol, Dinoprostone and Bard Catheter
- Conditions
- Interventions
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2008-01-28
- Lead Sponsor
- Karolinska University Hospital
- Target Recruit Count
- 592
- Registration Number
- NCT00602095
Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess
- First Posted Date
- 2007-10-17
- Last Posted Date
- 2007-10-17
- Target Recruit Count
- 446
- Registration Number
- NCT00545194
- Locations
- 🇫🇷
Olympe de Gouges Women Health Centre, Bretonneau University Hospital, Tours, France
Combined Agent Randomized Trial of Induction of Labor
- Conditions
- First Posted Date
- 2007-07-20
- Last Posted Date
- 2007-07-20
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 210
- Registration Number
- NCT00504465
- Locations
- 🇺🇸
New York Hospital Medical Center of Queens, Flushing, New York, United States
🇺🇸The Brooklyn Hospital Center, Brooklyn, New York, United States
🇺🇸Weill Medical College of Cornell University, New York, New York, United States
Comparing the Effect of Vaginal Misoprostol With Dinoprostone in Term Pregnancies
- Conditions
- First Posted Date
- 2007-02-08
- Last Posted Date
- 2007-06-01
- Lead Sponsor
- Hormozgan University of Medical Sciences
- Registration Number
- NCT00432588
- Locations
- 🇮🇷
Shariaty Maternity Hospital, Tehran, Iran, Islamic Republic of
Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2
- First Posted Date
- 2006-09-11
- Last Posted Date
- 2007-08-01
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 12
- Registration Number
- NCT00374530
- Locations
- 🇩🇰
Danish Headache Center, Glostrup, Denmark
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.