Acetazolamide
- Generic Name
- Acetazolamide
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C4H6N4O3S2
- CAS Number
- 59-66-5
- Unique Ingredient Identifier
- O3FX965V0I
- Background
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of...
- Indication
For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
- Associated Conditions
- Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication
- Associated Therapies
- Urine alkalinization therapy
Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition
- Conditions
- Interventions
- First Posted Date
- 2008-10-27
- Last Posted Date
- 2014-02-06
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 26
- Registration Number
- NCT00780325
- Locations
- 🇺🇸
Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States
Buspirone as a Potential Treatment for Recurrent Central Apnea
- Conditions
- Interventions
- First Posted Date
- 2008-09-04
- Last Posted Date
- 2016-03-14
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 8
- Registration Number
- NCT00746954
- Locations
- 🇺🇸
VA Medical Center, Cleveland, Cleveland, Ohio, United States
Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude
- Conditions
- First Posted Date
- 2008-07-14
- Last Posted Date
- 2014-05-20
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 49
- Registration Number
- NCT00714740
- Locations
- 🇨🇭
Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy
- Conditions
- Interventions
- First Posted Date
- 2008-03-13
- Last Posted Date
- 2008-03-13
- Lead Sponsor
- Shiraz University of Medical Sciences
- Target Recruit Count
- 240
- Registration Number
- NCT00634491
- Locations
- 🇮🇷
Fars Heart Foundation , Kowsar hospital, Shiraz, Iran, Islamic Republic of
Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure
- First Posted Date
- 2007-08-17
- Last Posted Date
- 2016-01-28
- Lead Sponsor
- Centro Cardiologico Monzino
- Target Recruit Count
- 20
- Registration Number
- NCT00517426
- Locations
- 🇮🇹
Centro Cardiologico Monzino, University of Milan, Milan, Italy
A Combined Surgical and Medical Approach in Mild Sleep Apnea
- Conditions
- First Posted Date
- 2007-07-06
- Last Posted Date
- 2007-07-06
- Lead Sponsor
- University Hospital, Antwerp
- Registration Number
- NCT00497120
- Locations
- 🇧🇪
University Hospital Antwerp, Edegem, Antwerp, Belgium
Treatment of High Altitude Polycythemia by Acetazolamide
- First Posted Date
- 2007-01-22
- Last Posted Date
- 2013-01-24
- Target Recruit Count
- 55
- Registration Number
- NCT00424970
- Locations
- 🇵🇪
University Cayetano Heredia, Lima, Peru
Treatment of Orthostatic Intolerance
- Conditions
- Interventions
- Drug: AtomoxetineDrug: AcetazolamideDietary Supplement: MelatoninOther: NO DrugDrug: Isosorbide DinitrateRadiation: PlaceboDevice: Breathing DeviceOther: Drinking WaterProcedure: IV SalineDevice: Abdominal binderDrug: IndomethacinDrug: MidodrineDrug: MecamylamineDrug: ClonidineDrug: EntacaponeDrug: memantineDrug: ModafinilDrug: OctreotideDrug: SertralineDrug: Atomoxetine & PropranololDrug: Entacapone & PropranololDrug: PropranololDrug: Modafinil & Propranolol
- First Posted Date
- 2005-12-06
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Satish R. Raj
- Target Recruit Count
- 150
- Registration Number
- NCT00262470
- Locations
- 🇺🇸
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee, United States
Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis
- Conditions
- Interventions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2014-01-20
- Lead Sponsor
- University of Oslo School of Pharmacy
- Target Recruit Count
- 70
- Registration Number
- NCT00222534
- Locations
- 🇳🇴
Department of Internal Medicine, Sorlandet Sykehus Kristiansand, Kristiansand, Norway
🇳🇴Department of Internal Medicine, Aker University Hospital, Oslo, Norway
🇳🇴Department of Respiratory Medicine, Haukeland University Hospital, Bergen, Norway
Treatment of Orthostatic Hypotension in Autonomic Failure
- Conditions
- Interventions
- Drug: AtomoxetineDrug: placeboDrug: AcarboseDevice: inflatable abdominal binder (sham)Drug: Pyridostigmine BromideDrug: YohimbineDrug: Midodrine HClDrug: ModafinilDrug: OctreotideOther: water intakeDrug: Diphenhydramine HydrochlorideDrug: Ranitidine HCLDrug: TranylcypromineDrug: Ergotamine/ CaffeineDrug: CelecoxibDrug: PseudoephedrineDrug: MethylphenidateDrug: IndomethacinDrug: IbuprofenDrug: Oxymetazoline 0.05% nasal solutionDietary Supplement: BovrilDrug: AcetazolamideDrug: Rivastigmine tartrateDrug: Carbidopa/levodopaDevice: Inflatable abdominal binder
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 389
- Registration Number
- NCT00223691
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.